Publications by authors named "Cara Gardner"
Article Synopsis
- - Epilepsy and Alzheimer's disease exhibit shared neurodegenerative features, including seizures and cognitive decline; however, the underlying molecular mechanisms are not fully understood.
- - The study highlights the significant increase in Fyn-tau interactions following seizure induction, indicating potential therapeutic targets for modifying brain pathology in both conditions.
- - Findings suggest that inhibiting Fyn via saracatinib can reduce pathological interactions and phosphorylation in models of epilepsy, pointing to promising avenues for treatment in human cases.
Organophosphate (OP) nerve agents are a threat to both the military and civilians. OP exposure causes cholinergic crisis and status epilepticus (SE) because of irreversible inhibition of acetylcholinesterase that can be life-threatening if left untreated. OP survivors develop long-term morbidity, such as cognitive impairment and motor dysfunction, because of oxidative stress and progressive neuroinflammation and neurodegeneration, which act as disease promoters.
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