Irish Prostate Cancer Outcomes Research (IPCOR) registry: cohort profile.

Purpose: To describe the Irish Prostate Cancer Outcomes Research (IPCOR) registry. The cohort was collected to inform and improve the prostate cancer journey of men in Ireland.

Participants: Established in 2015, IPCOR was a unique large-scale prospective cohort study registering men with prostate cancer in Ireland.

Are we there yet? Closing the gap of prostate cancer presentation disparities in Ireland.

Introduction: The Irish Prostate Cancer Outcomes Research (IPCOR) Study collected longitudinal data on men newly diagnosed with Prostate Cancer (PC). Understanding the nuances of disease presentation is essential, considering the high incidence of PC in Ireland. This study aims to characterise disease presentation features, identify factors related to socio demographic disparities in presentation following opportunistic screening, and shed light on potential inequality challenges within Ireland's healthcare structure.

Clinical decision support for gastrointestinal panel testing.

Objective: This study aimed to assess the impact of clinical decision support (CDS) to improve ordering of multiplex gastrointestinal polymerase chain reaction (PCR) testing panel ("GI panel").

Design: Single-center, retrospective, before-after study.

Setting: Tertiary care Veteran's Affairs (VA) Medical Center provides inpatient, outpatient, and residential care.

Occupational Health Providers' Perceptions of Employee Vaccine Hesitancy.

Objective: This study examined the perspectives of occupational health providers (OHPs) on the most frequently encountered clinically relevant reasons for employee vaccine hesitancy.

Methods: We conducted an anonymous, online, cross-sectional survey of US OHPs ( N = 217). The survey asked OHPs about the major reasons that employees cite for being unwilling to receive the following three categories of vaccines: COVID-19, annual influenza, and others relevant to the workplace.

Role of Dietary Macronutrients and Fatty Acids in Obesity and Metabolic Risk in Older Adults.

The aim of the study was to examine the role of dietary consumption of different types of fatty acids on metabolic risk factors and regional fat deposition in older men and women. We hypothesized that saturated fatty acid (SFA) intake, monounsaturated fatty acid (MUFA) and low intake of polyunsaturated fatty acids (PUFA) would be associated with markers of insulin resistance, hyperlipidemia, and hypertriglyceridemia. Sedentary, overweight and obese (body mass index: 29-48 kg/m) adults (N=20) aged 45-78 years underwent two-hour oral glucose tolerance test, blood draw, DXA scan, and completed seven-day diet records.

Usual and Dual-Task Walking Speed: Implications for Pedestrians Crossing the Road.

Objective: In many countries, pedestrian light crossings require a minimum walking speed of 1.2 m/s. This study examined the proportion of adults in a nationally representative sample whose usual and dual-task walking speeds are <1.

Prevalence of age-related macular degeneration in the Republic of Ireland.

Background: Age-related macular degeneration (AMD) remains the most common cause of visual loss among subjects over 50 years of age in the developed world. The Irish Longitudinal study on Ageing (TILDA) is a population-based study of subjects aged 50 years or older, designed to investigate factors that influence ageing, and has enabled this investigation of the prevalence of AMD in the Republic of Ireland (ROI).

Methods: Data collected from a nationally representative sample of community-living older adults aged 50 years and over in ROI over the period November 2009 to July 2011.

Stressful life events and orthostatic blood pressure recovery in older adults.

Objective: The majority of the literature on stress and blood pressure (BP) concerns the increased risk of cardiovascular morbidity and mortality from high BP. Because the sympathetic nervous system is critical to the maintenance of orthostatic BP, it was hypothesized that older adults who have experienced more stressful life events (SLEs) would be more likely to show impaired recovery of BP in response to orthostatic stress.

Method: A total of 3,765 participants (Mage = 61.

Atrial fibrillation is associated with impaired mobility in community-dwelling older adults.

Objectives: To examine the independent associations between atrial fibrillation (AF) and objectively measured mobility in a nationally representative cohort.

Design: Wave 1 of The Irish Longitudinal Study on Ageing (TILDA), a population-based study assessing health, economic, and social aspects of ageing.

Setting: Community-dwelling adults completed a home-based interview and a center-based health assessment.

The lasting legacy of childhood adversity for disease risk in later life.

Objective: There has been an increased interest in the role of the childhood social environment in the etiology of adult diseases in recent years. The present study examines whether the experience of adversity during childhood increases risk for disease in later life independent of later life socioeconomic, behavioral, and psychosocial factors.

Method: The study involved a nationally representative sample of 6,912 persons aged 50 years and older who were participating in the first wave of the Irish Longitudinal Study on Ageing.

Younger age as a prognostic indicator in breast cancer: a cohort study.

Background: The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort.

Methods: Data was acquired from a review of charts and the prospectively reviewed GUH Department of Surgery database.