Background: Cardiac repolarization has been shown to be shorter and faster in men compared with women. In this study, we examined the electrocardiographic pattern of repolarization in patients with abnormal plasma levels of testosterone to gain insight into the role that this hormone plays in modulating repolarization.
Methods And Results: Repolarization was measured in 27 castrated men, 26 women with virilization, and 53 control subjects pair-matched for age and sex.
Background: Although sex-dependent differences in cardiac repolarization have been known for many years, few attempts have been carried out to define the individual contribution of each electrocardiographic (ECG) repolarization variable to the sex-dependent pattern.
Method And Results: We analyzed several ECG repolarization variables that reflect both the duration and the rate of repolarization in 500 normal healthy subjects between the ages of 20 and 80 years (250 men and 250 women) and distributed into 5 groups according to age. Cardiac repolarization, measured in the precordial lead exhibiting the highest T-wave amplitude, was found to be shorter and faster in normal men compared with normal women (P <.