Machine Learning-Assisted Automatically Electrochemical Addressable Cytosensing Arrays for Anticancer Drug Screening.

The high-throughput and accurate screening of anticancer drugs is crucial to the preclinical assessment of candidate drugs and remains challenging. Herein, an automatically electrochemical addressable cytosensor (AEAC) for the efficient screening of anticancer drugs is reported. This sensor consists of sectionalized laser-induced graphene arrays decorated by the rhombohedral TiO and spherical Pt nanoparticles (LIG-TiO-Pt) with high electrocatalytic activity for HO and a homemade Ag/Pt electrode couple fixed onto the robot arm.

Graphene/metal-organic framework nano-sandwiches derived N, P-codoped porous carbon nanosheets as robust material for electrochemical analysis.

Construction of novel two-dimensional porous carbon nanosheets with superior electrochemical activity is of great challenge. Here, graphene/ZIF-8 nano-sandwiches derived N, P-codoped porous carbon nanosheets (N, P-codoped PCN) was easily obtained by sequential room temperature self-assembly and high-temperature carbonization method. Relative to the widely used physically exfoliated graphene nanosheets (GN) and graphene/ZIF-8 derived N-doped porous carbon nanosheets (N-doped PCN), N, P-codoped PCN displayed larger active surface, faster electron transport ability and stronger physical adsorption ability, which can be ascribed to the dual doping effect of heteroatoms N and P.

Metal Centers and Organic Ligands Determine Electrochemistry of Metal-Organic Frameworks.

The properties and applications of metal-organic frameworks (MOFs) can be tuned by their metal centers and organic ligands. To reveal experimentally and theoretically the influence of metal centers and ligands on electrochemical performance of MOFs, three MOFs with copper or zinc centers and organic ligands of 2-methylimidazole (2MI) or 1,3,5-benzenetricarboxylic acid (H BTC) are synthesized and characterized in this study. 2D and porous Cu-2MI exhibits a larger active area, faster electron transfer capability, and stronger adsorption capacity than bulk Cu-BTC and dodecahedron Zn-2MI.

Simultaneous detection of 4-chlorophenol and 4-nitrophenol using a TiCT MXene based electrochemical sensor.

Developing a sensitive and rapid detection method for 4-chlorophenol (4-CP) and 4-nitrophenol (4-NP) is very important due to their high toxicity. In this work, bulk TiAlC powder was etched to TiCT for the first time through a hydrothermal reaction in NaF/HCl solution. After ultrasonication in -methylpyrrolidone (NMP), TiCT powder was successfully exfoliated into multilayered TiCT nanosheets ( TiCT MXene).

Cu-BTC frameworks based electrochemical sensor for hazardous malachite green in aquaculture.

Malachite green (MG) has been widely used for controlling external fungi and parasites in the aquaculture. However, MG has been proven to be very hazardous, and the detection of MG in aquaculture environment is crucial for determining whether MG has been used within the allowed limit and for protecting the environment. Herein, a kind of copper based metal-organic frameworks (MOFs) was prepared using copper nitrate and 1,3,5-benzenetricarboxylic acid (HBTC) as raw materials.

Triethylamine-controlled Cu-BTC frameworks for electrochemical sensing fish freshness.

The simultaneous determination of xanthine (XA) and hypoxanthine (HXA) has been proved to be a feasible approach for the assessment of fish freshness. In this study, copper(II) nitrate and 1,3,5-benzenetricarboxylic acid (HBTC) were used as precursors to prepare various Cu-BTC frameworks with the addition of various amounts of triethylamine at room temperature. The characterization of X-ray diffraction, Fourier-transform infrared spectroscopy and Raman spectroscopy testified that the obtained materials are Cu-BTC frameworks.

Strategy for Highly Sensitive Electrochemical Sensing: In Situ Coupling of a Metal-Organic Framework with Ball-Mill-Exfoliated Graphene.

A highly sensitive electrochemical sensing system is developed via in situ integration of Cu-based metal-organic frameworks (Cu-BTC, BTC = 1,3,5-benzenetricarboxylic acid) and high-conductivity ball-mill-exfoliated graphene (Cu-BTC@GS) by a simple method. The as-synthesized Cu-BTC@GS hybrids display remarkably enhanced electrochemical activity due to the synergistic effect resulting from the integration. Compared to those of the pristine GS, the introduction of Cu-BTC nanoparticles leads to significant improvement in the surface area and porosity, as revealed by the nitrogen adsorption-desorption analysis.