Publications by authors named "Cao-Li Tang"
Article Synopsis
- A new study has developed a saliva biopsy method for detecting nasopharyngeal carcinoma (NPC), showing the potential of using oral samples for diagnosis.
- Researchers collected 907 samples, including saliva and swabs, and found significant increases in Epstein‒Barr virus (EBV) DNA methylation in NPC patients.
- The study suggests that using saliva and oropharyngeal swabs together can improve NPC detection and indicates the possibility of self-sampling for home-based screening.
Article Synopsis
- EBV (Epstein-Barr Virus) is linked to various cancers, and understanding its methylation profiles in tumor tissues is crucial for cancer research.
- A study utilizing EBV methylation capture sequencing found distinct methylation patterns in different tumor types, with significant differences identified, especially in EBVaGC compared to others.
- The research also established a diagnostic model with high accuracy for differentiating nasopharyngeal carcinoma (NPC) from nasal NKTCL, suggesting that specific EBV CpG sites may aid in cancer diagnosis and understanding EBV's role in tumor formation.
Saliva sampling is a non-invasive method, and could be performed by donors themselves. However, there are few studies reporting biomarkers in saliva in the diagnosis of NPC. A total of 987 salivary samples were used in this study.
View Article and Find Full Text PDFDetecting EBV DNA load in nasopharyngeal (NP) brushing samples for the diagnosis of nasopharyngeal carcinoma (NPC) has attracted widespread attentions. Currently, NP brush sampling mostly relies on endoscopic guidance, and there are few reports on diagnostic markers suitable for nonguided conditions (blind brush sampling), which is of great significance for extending its application. One hundred seventy nasopharyngeal brushing samples were taken from 98 NPC patients and 72 non-NPC controls under the guidance of endoscope, and 305 blind brushing samples were taken without endoscopic guidance from 164 NPC patients and 141 non-NPC controls (divided into discovery and validation sets).
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