Publications by authors named "Cao Yu"

This study aims to explore the clinical characteristics and prognostic factors in patients with diquat (DQ) poisoning and to develop a clinical risk assessment model to improve diagnosis and treatment strategies. Data from 60 patients with DQ poisoning, including basic characteristics, poisoning severity, and inflammatory response indicators, were collected. The plasma concentration of DQ was measured using liquid chromatography-mass spectrometry.

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Rice ( L.) feeds half the world's population and serves as one of the most vital staple food crops globally. The brown planthopper (BPH, Stål), a major piercing-sucking herbivore specific to rice, accounts for large yield losses annually in rice-growing areas.

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Background: Malignant pleural mesothelioma (MPM) is primarily treated with a combination therapy based on lung pleurectomy in the early stage or pemetrexed combined with platinum-based chemotherapy in the late stage. However, these standard therapies do not significantly improve survival and are associated with significant adverse reactions.

Case Description: In February 2017, a 63-year-old male patient was admitted to Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University coughing for 1 month and experienced chest tightness and chest pain for 2 days.

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Membrane budding is vital for various cellular processes such as synaptic activity regulation, vesicle transport and release, and endocytosis/exocytosis. Although protein-mediated membrane budding has been extensively investigated, the effects of the lipid asymmetry of the two leaflets and the asymmetrically electrical environments of the cellular membrane on membrane budding remain elusive. In this work, using coarse-grained molecular dynamics simulations, we systematically investigate the impacts of lipid bilayer asymmetry and external electric fields mimicking the asymmetric membrane potential on the membrane budding.

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This study aimed to investigate the efficacy of a pre-procedural white blood cell (WBC) count in the prediction of contrast-induced acute kidney injury (CI-AKI) risk in coronary artery disease patients receiving a percutaneous coronary intervention (PCI). This observational study comprises a sample of 1,013 coronary artery disease patients (including ACS and stable angina) receiving PCI, gathered from September 2015 to July 2017. CI-AKI incidence in the study population was 4.

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The facile construction of transmissive films with ultrabroad optical activity, spanning from deep-ultraviolet to short-wave infrared and offering convenient tunability across a wide range, is highly desirable for applications in sensing, imaging, and communication. However, achieving this remains challenging. Here, an easily applied wet-stretching method is introduced that simultaneously orients polymeric substrates and surface-coated plasmonic nanorods.

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Article Synopsis
  • - Schizophrenia (SCZ) patients experienced higher rates of SARS-CoV-2 infection and mortality during the COVID-19 pandemic compared to those with other mental disorders, but the reasons for this remain unclear.
  • - The review suggests that common molecular pathways linked to energy metabolism, immune disruptions, and central nervous system abnormalities may play a role in the heightened risks for SCZ patients during COVID-19.
  • - Additionally, factors such as sociodemographic challenges, limited access to psychiatric care, and barriers to vaccination were discussed as reasons behind the elevated infection and mortality rates in SCZ individuals.
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Purpose: To investigate the mechanism underlying the effects of Tongdu Tiaoshen electroacupuncture in the treatment of cerebral ischemia-reperfusion (I/R) injury.

Methods: Sixty adult male Sprague-Dawley (SD) rats were randomly allocated to five groups (n=12): Sham, I/R, electroacupuncture (EA), BBG (P2X7R inhibitor), and MCC950 (NLRP3 inhibitor). The EA group received acupuncture at Shenting (GV24), Baihui (GV20), and Dazhui (GV14) points with a stimulation frequency of 2/5 Hz, intensity of 2 mA, and a duration of 40 min.

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An N-heterocyclic carbene (NHC) ligand supports a stable [NiH] core, formally dinickel(I). This diamagnetic cation complex features a bent hydride bridge and a Ni···Ni distance, 2.9926(5) Å, larger than two covalent radii.

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The main function of the dynamic scan and stare imaging system is to quickly and continuously search a large area and perform high-resolution imaging. To eliminate image motion during the scanning process, this paper proposes an image motion compensation control method with dual-channel control. First, an improved model-assisted active disturbance rejection control is proposed, in which an auxiliary model is integrated into the algorithm to improve the control accuracy and response speed of the rotation rate of the platform.

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  • - Nickel-rich layered oxides are a promising material for high-energy Li-ion batteries, but their performance suffers from structural issues caused by Ni/Li antisite disorder, leading to capacity loss and shorter lifespan.
  • - The proposed rejuvenation strategy uses magneto-electrochemical activation to stabilize the positive electrode, transitioning Ni to a lower spin state and encouraging Li mobility, which helps recover the material's lithium sites and extend battery life.
  • - This method successfully revitalizes an aged Li-ion pouch cell, increasing its capacity by 10% (from 6.49 to 7.14 Ah) and demonstrating the potential to convert low-quality electrodes into high-quality ones through this upcycling process.
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Background: Clesrovimab is a human half-life extended mAb in phase 3 evaluation for the prevention of RSV disease in infants. ADA were observed at late time points in a phase 1b/2a study where clesrovimab was well tolerated with an extended half-life of ∼45 days.

Methods: Serum samples at days 150, 365 and 545 post-dose were assayed for ADA titers.

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is a newly discovered bark beetle in China that significantly threatens the American sweetgum . In recent years, this pest has spread from its original habitat to many surrounding cities, causing substantial economic and ecological losses. Considering the wide global distribution of its host, , this pest is likely to continue to spread and expand.

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Objectives: There have been conflicting reports detailing the effect of sex match between transplant donor and recipient on the outcome of solid-organ transplants. We investigated the effect of donor-recipient sex match on allograft function and survival outcomes after simultaneous pancreas-kidney transplant at a single transplant center in China.

Materials And Methods: We retrospectively reviewed data for 120 simultaneous pancreas-kidney transplant recipients treated at our center during the period from January 2015 to January 2020.

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  • * This study investigates the therapeutic effects and mechanisms of OVs that encode 4-1BBL and IL15 in combination with TIL therapy on HCC using mouse models and flow cytometry.
  • * Findings demonstrate that the combination therapy reduces tumor size and enhances immune memory, while also turning tumor cells into antigen-presenting cells and activating T cells, indicating promising clinical applications for treating HCC.
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The "gut-brain axis" is involved in many physiological processes. However, its role in regulating mammary gland (MG) development remains unknown. In this study, we established the mice model of bilateral subdiaphragmatic vagotomy (Vago) to clarify the effects of "gut-brain axis" on MG development in pubertal mice.

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  • Gongju, a traditional Chinese medicinal herb, contains chlorogenic acid (CGA), and the study explores the increased CGA levels in autooctoploid Gongju compared to its parental tetraploid variety across different flowering stages.* -
  • The research utilized integrated transcriptome and metabolome analyses to identify the molecular mechanisms affecting CGA biosynthesis, revealing significant differences in gene expression and metabolite accumulation between the two varieties at budding, early flowering, and full flowering stages.* -
  • Key findings included the discovery that specific enzymes and transcription factors crucial for CGA synthesis were more actively expressed in octoploid Gongju compared to tetraploid, indicating their role in the enhanced CGA production during flowering.*
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Hydrochlorothiazide (HCTZ) is a widely utilized diuretic for the treatment of hypertension. The photosensitivity of HCTZ has been recognized for six decades, with UVA being considered the primary culprit. However, the precise molecular mechanism of HCTZ sensitizing skin to UV radiation remains unknown.

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The pathophysiology of cardiovascular disease (CVD) is complex and presents a serious threat to human health. Cardiomyocyte loss serves a pivotal role in both the onset and progression of CVD. Among various forms of programmed cell death, ferroptosis, along with apoptosis, autophagy and pyroptosis, is closely linked to the advancement of CVD.

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This study examines the impact of the Affordable Care Act (ACA) on health insurance coverage among rent-burdened households-those spending more than 30% of their income on rent-and non-rent-burdened households. Using data from American Community Survey, we find that Medicaid take-up rate increased 8.88 percentage points (pp) among rent-burdened households and 7.

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Background: Pulmonary arterial hypertension (PAH) is characterized by lipid accumulation and mitochondrial dysfunction. This study was designed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α) on fatty acid uptake and mitophagy in PAH.

Methods: Peripheral blood samples were obtained from PAH patients.

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To address immune escape, multi-specific CAR-T-cell strategies use natural ligands that specifically bind multiple receptors on malignant cells. In this context, we propose a split CAR design comprising a universal receptor expressed on T cells and ligand-based switch molecules, which preserves the natural trimeric structure of ligands like APRIL and BAFF. Following optimization of the hinges and switch labeling sites, the split-design CAR-T cells ensure the native conformation of ligands, facilitating the optimal formation of immune synapses between target cancer cells and CAR-T cells.

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Designing potential agents and constructing hydrophilic nano-hydrogel platforms for biomedical and pharmaceutical applications, especially for polyoxometalate-based metal-organic frameworks (PMOF), present both great desirability and significant challenges. A unique open porous Cu(I)-isopolymolybdate-based metal-organic framework (CCUT) has been self-assembled through ionothermal processes for in vivo synergistic anti-cancer therapy. The periodicity of Drugs@CCUT-1 (nano-crystals of CCUT after cation exchange and anti-cancer drugs upload) has been investigated by synchrotron wide-angle X-ray scattering, confirming the lattice structure unchanged.

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