Genome-wide analysis of IDD genes identifies as a regulator of leaf angle.

The INDETERMINATE DOMAIN (IDD) gene family, encoding a class of C2H2 transcription factor, played diverse roles in land plants. The IDD family in tobacco () has not been characterized. In this study, 26 NtIDDs were identified in the tobacco genome.

A Smart Semi-Implantable Device Integrating Microchannel-Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification.

Monitoring deep wounds is challenging but necessary for high-quality medical treatment. Current methodologies for deep wound monitoring are typically limited to indirect clinical symptoms or costly non-real-time imaging diagnosis. Herein, a smart system is proposed that enables in situ monitoring of deep wounds' status through a semi-implantable device composed of 2 seamlessly connected functional components: 1) the well-designed, microchannel-structured sampling needles that efficiently and conveniently collect samples from deep wound anatomical locations, and 2) the multiplex biochemical testing compartment that facilitates the immediate and persistent detection of multiple biochemical indicators based on a color image processing software accessible to a conventional smartphone.

Enabling Aqueous Phase Long-lived Deep-blue Phosphorescence With Layered Double Hydroxide.

Aqueous-phase phosphors are of utmost importance for a myriad of applications. However, the emission wavelengths of the current aqueous organic room-temperature phosphorescent (RTP) materials are limited to green and red bands, while the blue part is rarely reported, thus limiting the development of a full-color RTP system. Theoretically, carboxylated benzene is expected to be blue phosphorescence-emissive, but only green phosphorescence is observed in solid, due to the strong intermolecular π-π stacking that decreases the energy gap.

Combination of age-adjusted d-dimer, platelet distribution width and other factors predict preoperative deep venous thrombosis in elderly patients with femoral neck fracture.

Purpose: This retrospective cohort study aimed to identify factors associated with preoperative deep venous thrombosis (DVT) in elderly patients with femoral neck fractures, and to investigate whether combining these factors could improve the ability to predict DVT.

Method: Medical records and laboratory test results were reviewed patients presenting with a femoral neck fracture and receiving routine chemoprophylaxis for DVT between January 2020 and December 2023 in a tertiary referral, university-affiliated hospital. Preoperative DVT was confirmed by Doppler ultrasound or CT venography.

Effect of pre-deformation on microstructure and mechanical properties of a fine-grained 2A97 alloy.

This study investigates the effect of pre-deformation by cold rolling after solution annealing on the microstructure and properties of the fine-grained Al-Li alloy 2A97. Electron backscatter diffraction (EBSD), X-ray diffraction (XRD) and transmission electron microscopy (TEM) were used to characterize grain boundaries, dislocations, precipitates and calculate their contribution to strength. It is found that the changes in precipitation behavior predominantly account for the enhanced tensile properties observed in the deformed alloys, where yield and tensile strengths are increased by 85 MPa and 63 MPa, respectively.

A Lionfish-Skin-Inspired Intrinsic Antifouling Coating for Full-Ocean-Depth up to 7730 Meters.

As marine equipment advances from shallow to deep-sea environments, the demand for high-performance antifouling materials continues to increase. The lionfish, a species inhabiting both deep-sea and shallow coral reefs, prevents fouling organism adhesion via its smooth, mucus-covered skin, which contains antimicrobial peptides. Inspired by lionfish skin, this work integrates zwitterionic segments with hydration-based fouling-release properties and the furan oxime ester structure with intrinsic antibacterial activity to develop a silicone-based antifouling coating capable of operating from shallow to deep-sea environments.

Design, Synthesis, and Biological Evaluation of 3,4-Dihydroisoquinolin-1()-one Derivatives as Protein Arginine Methyltransferase 5 Inhibitors for the Treatment of Non-Hodgkin's Lymphoma.

Through catalyzing the transfer of methyl groups onto the guanidinium of arginine, protein arginine methyltransferase 5 (PRMT5) was essential to the cell growth of cancer cells. By utilizing a scaffold hopping strategy, a novel series of 3,4-dihydroisoquinolin-1()-one derivatives were designed and synthesized. Through a systematic SAR study, demonstrated excellent PRMT5 inhibitory activity, potent antiproliferative activity against Z-138, favorable pharmacokinetic profiles, and low hERG toxicity.

A nomogram to distinguish noncardiac chest pain based on cardiopulmonary exercise testing in cardiology clinic.

Background: Psychological disorders, such as anxiety and depression, are considered to be one of the causes of noncardiac chest pain (NCCP). And these patients can be challenging to differentiate from coronary artery disease (CAD), leading to a considerable number of patients still undergoing angiography. We aim to develop a practical prediction model and nomogram using cardiopulmonary exercise testing (CPET), to help identify these patients.

Effectiveness and compliance of telemedicine on blood pressure management in poststroke patients: a systematic review and meta-analysis of randomised controlled trials.

Objective: To examine the effectiveness of telemedicine on blood pressure control and compliance.

Design: Systematic review and meta-analysis.

Data Sources: A search of PubMed, Web of Science, Embase and Cochrane Library for studies of randomised controlled trials (RCTs) of telemedicine on blood pressure control in poststroke survivors from the time of their construction until November 2023.

Dynamic analysis of frequency specificity in multilayer brain networks.

The brain is a highly complex and delicate system, and its internal neural processes are manifested as the interweaving and superposition of multi-frequency neural signals. However, traditional brain network studies are often limited to the whole frequency band or a specific frequency band, ignoring the potentially profound impact of the diversity of information within the frequency on the dynamics of brain networks. To comprehensively and deeply analyze this phenomenon, the present study is devoted to exploring the specific performance of brain networks at different frequencies.

Fermentation process of tobacco leaves drives the specific changes of microbial community.

Background: The changes of microbial community on tobacco leaves are affected by several factors during fermentation. However, the relative contribution of different factors in determining microbial community is not clear. This study investigated the effects of fermentation time (fermentation for 0, 3, 6, 9 and 12 months), leaf position (middle and top tobacco leaves) and fermentation site (Longyan and Xiamen warehouses) on bacterial community of tobacco leaves using 16 S rDNA sequencing.

Automatic Pavlov ratio measurement method based on spinal landmarks identification by a deep-learning model.

Background: Cervical canal stenosis is one of the important pathogenic factors of cervical spondylosis. The accuracy of the Pavlov ratio measurement is crucial for the diagnosis and treatment of cervical spinal stenosis. Manual measurement is influenced by observer variability, accompanied by its inefficiency, which affects clinical evaluation.

Revealing critical mechanisms involved in carbon nanosol-mediated tobacco growth using small RNA and mRNA sequencing in silico approach.

Nanomaterials have been shown to promote crop growth, yield and stress resistance. Carbon nanosol (CNS), a type of nanomaterial, is used to regulate tobacco shoot and root growth. However, information about the application of CNS to crop plants, especially tobacco, is still limited.

CMR-BENet: A confidence map refinement boundary enhancement network for left ventricular myocardium segmentation.

Background And Objective: Left ventricular myocardium segmentation is of great significance for clinical diagnosis, treatment, and prognosis. However, myocardium segmentation is challenging as the medical image quality is disturbed by various factors such as motion, artifacts, and noise. Its accuracy largely depends on the accurate identification of edges and structures.

Conformational Analysis of Swallowtail Motifs in Porphyrins.

Aqueous solubilization of porphyrins, often accomplished with appended polar aryl groups, can also be achieved with symmetrically branched alkyl (i.e., swallowtail) groups terminated with polar moieties.

Molecular pathogen profiling of COVID-19 coinfections.

Objective: This study aims to investigate the prevalence, pathogen spectrum, clinical characteristics, and prognosis-related factors of other respiratory pathogens in COVID-19-infected patients, and to explore the application of molecular detection methods in the epidemiological investigation of multiple pathogen infections.

Methods: Respiratory samples and clinical data from 384 patients with outpatient and inpatient respiratory infections were collected and analyzed. Multiplex PCR and capillary electrophoresis were conducted to detect the distribution characteristics of 26 pathogen species, comprising 13 viruses, 13 bacteria.

A systematic review of racial health disparities among children and youth with physical disabilities.

Purpose: Children and youth who belong to a racially minoritized group commonly experience multiple and complex forms of discrimination and health disparities. The purpose of this review was to explore racial disparities in health care and health outcomes among children and youth with physical disabilities.

Methods: Six international databases (Ovid Medline, Healthstar, Embase, PsycINFO, Scopus, and Web of Science) were searched and screened for inclusion.

Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth.

Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuroendocrine neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar tumor with a propensity for invading the hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate the molecular pathology, clinical manifestations, and transcriptomic profiles of papillary craniopharyngioma.

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1 Macrophages for Infectious Bone Defect Regeneration.

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired bone healing. Icam1 macrophages were identified as crucial and previously unrecognized regulators in the repair of bone defects, where impaired oxidative phosphorylation within this macrophage subset represents a significant barrier to effective bone regeneration. To address this challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles were synthesized with magnetic and ultrasonic properties.

Therapeutic potential of Xihuang Pill in colorectal cancer: Metabolomic and microbiome-driven approaches.

Introduction: The Xihuang Pill (XHP), a venerated traditional Chinese medicine, has demonstrated significant anti-cancer capabilities. Despite its proven efficacy, the scarcity of comprehensive pharmacological studies limits the widespread application of XHP. This research endeavor seeks to demystify the therapeutic underpinnings of XHP, particularly in the realm of colorectal cancer (CRC) therapy.

Designing Silk Biomaterials toward Better Future Healthcare: The Development and Application of Silk-Based Implantable Electronic Devices in Clinical Diagnosis and Therapy.

Implantable medical electronic devices (IMEDs) have attracted great attention and shown versatility for solving clinical problems ranging from real-time monitoring of physiological/ pathological states to electrical stimulation therapy and from monitoring brain cell activity to deep brain stimulation. The ongoing challenge is to select appropriate materials in target device configuration for biomedical applications. Currently, silk-based biomaterials have been developed for the design of diagnostic and therapeutic electronic devices due to their excellent properties and abundant active sites in the structure.

Cellulose Acetate Membranes: Antibacterial Strategy and Application-A Review.

Developing antibacterial and biodegradable cellulose acetate (CA) membrane materials is one of the main challenges in multiple application fields. CA membrane materials are widely used in gas purification, water purification, and biomedical fields due to their environmental friendliness, high chemical and mechanical stability, excellent processability, and low cost. However, antibacterial modification of CA membrane materials to enhance their utilization value in the application process has always been the direction of researchers' efforts.

The study on agitation and structure of orbitofrontal cortex subregion in first-episode drug-naïve patients with schizophrenia.

Agitation is one of the core symptoms of schizophrenia. The occurrence of agitation may be related to orbitofrontal cortex dysfunction. However, due to methodological heterogeneity, the relationship between agitation and orbitofrontal cortex subregions remains unclear.

Biogeography of a Global Plant Invader: From the Evolutionary History to Future Distributions.

Biological invasions pose a global challenge, affecting ecosystems worldwide and human societies. Knowledge of the evolutionary history of invasive species is critical to understanding their current invasion success and projecting their future spread. However, to date, few studies have addressed the evolutionary history and potential future spread of invaders simultaneously.