Publications by authors named "Cao Jin-Shan"
Article Synopsis
- Researchers developed a new drug delivery system using hen egg low-density lipoprotein (heLDL) to transport the antibiotic ceftiofur (CEF), creating a formulation called CEF-heLDL that has a stable structure and efficient drug loading.
- In lab tests, CEF-heLDL effectively entered cells and targeted lysosomes, showing better antibacterial activity, especially against Staphylococcus aureus, compared to the CEF-alone group.
- The study found that high doses of CEF-heLDL were safe for mice, suggesting that heLDL can be a cost-effective and safe carrier for delivering other antibiotics across cell membranes.
Bovine endometritis is one of the major postpartum diseases associated with infertility and subfertility, decreasing the benefit of dairy industry. It is important to develop alternate therapies for endometritis in the context of drug residues in the milk and hormone disorder in the estrous cycle. α7 nicotine acetylcholine receptor has been identified as the core of 'cholinergic anti-inflammatory pathway (CAP)', which is a potential drug target to inflammatory diseases.
View Article and Find Full Text PDFTo assess the prevalence of antimicrobial resistance and three classes of integrons in Escherichia coli (E. coli) strains (n=57) isolated from bovine endometritis in Inner Mongolia of China, antimicrobial susceptibility and the presence of three types of integrons were characterized. Most isolates were susceptible to ceftiofur, furazolidone, ciprofloxacin and enrofloxacin, while 57 isolates were all resistant to sulfamethoxydiazine and trimethoprim.
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