Publications by authors named "Cao Duong Ly"
Cancer remains a formidable global health challenge, demanding the exploration of innovative treatment modalities with minimized side effects. One promising avenue involves the synergistic integration of targeted photothermal/photodynamic therapy (PTT/PDT), utilizing specially designed functional nanomaterials for precise cancer diagnosis and treatment. This study introduces a composite biomaterial, anti-epidermal growth factor receptor-conjugated manganese core phthalocyanine bismuth (anti-EGFR-MPB), synthesized for precise cancer imaging and treatment.
View Article and Find Full Text PDFDeep learning (DL) is becoming more popular as a useful tool in various scientific domains, especially in chemistry applications. In the infrared spectroscopy field, where identifying functional groups in unknown compounds poses a significant challenge, there is a growing need for innovative approaches to streamline and enhance analysis processes. This study introduces a transformative approach leveraging a DL methodology based on transformer attention models.
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- Recent advancements in nanomaterials, specifically hydroxyapatite (HAp) doped with rare-earth elements like Yb and Gd, have shown promise for bioimaging applications due to improved bioactivity and imaging properties.
- The synthesis of Yb-Gd-HAp nanoparticles involved a wet precipitation method, followed by characterizing them for crystal structure, functional groups, and surface area, alongside the development of an imaging contrast agent by conjugating with IR783 dye and folic acid.
- In vitro studies confirmed the biocompatibility of the nanoparticles, and photodynamic therapy was tested on MDA-MB-231 breast cancer cells, demonstrating effective photosensitizing properties and reactive oxygen species generation.
Smart Low Level Laser Therapy System for Automatic Facial Dermatological Disorder Diagnosis.
IEEE J Biomed Health Inform
January 2023
Computer-aided diagnosis using dermoscopy images is a promising technique for improving the efficiency of facial skin disorder diagnosis and treatment. Hence, in this study, we propose a low-level laser therapy (LLLT) system with a deep neural network and medical internet of things (MIoT) assistance. The main contributions of this study are to (1) provide a comprehensive hardware and software design for an automatic phototherapy system, (2) propose a modified-UNet deep learning model for facial dermatological disorder segmentation, and (3) develop a synthetic data generation process for the proposed models to address the issue of the limited and imbalanced dataset.
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- * Using a co-precipitation approach, researchers created Co-HAp by replacing calcium ions with cobalt, and various techniques were applied to confirm the successful doping and characterize the nanoparticles.
- * Results showed that Co-HAp nanoparticles are non-toxic to breast cancer cell lines, have high drug loading capacity for doxorubicin (DOX), and exhibit enhanced fluorescence properties, making them suitable for drug delivery and imaging applications.
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- Photoacoustic (PA) microscopy is a technique used for imaging soft biological tissues by utilizing the contrast from optical absorption and ultrasound resolution, mainly focusing on microvasculature.
- The challenge in PA imaging arises from strong signals from the skin that obscure the visualization of deeper blood vessels, necessitating the development of better imaging techniques.
- This research introduces a modified U-Net deep learning model that effectively segments PA images, improving the clarity and resolution of in vivo imaging and demonstrating enhanced performance over previous methods.
Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan-polypyrrole nanocomposites (IR-CS-PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging.
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- Photoacoustic microscopy (PAM) is a noninvasive imaging technique that helps visualize the internal structures of living animals, but traditional PAM systems struggle with larger scanning areas.
- The researchers developed a new dual-channel PAM system with a custom slider-crank scanner, allowing for a wide scanning area of 24 mm and a fast B-scan speed of 32 Hz, maintaining high image quality.
- The system successfully imaged various biological specimens without contrast agents and demonstrated potential for monitoring blood flow with the use of magnetic contrast agents, highlighting its promise for biological research.
Multifunctional theranostic agents have recently attracted a great deal of attention in field of biomedicine. In the present work, folic acid-conjugated chitosan-functionalized graphene oxide (FA-CS-GO) has been developed as a new type of multifunctional nanomaterial for near-infrared fluorescence (FL)/photoacoustic imaging-(PAI) guided photothermal therapy (PTT) of cancer. In vitro results showed that the FA-CS-GO was able to completely destroy cancer cells under laser irradiation.
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