Publications by authors named "Cao Cun-Wei"
The diagnosis of Talaromyces marneffei infection in HIV-negative patients remains challenging. There is an urgent need for rapid and convenient methods to diagnose this complicated disease. The aim of this study was to evaluate the diagnostic efficiency of metagenomic next-generation sequencing (mNGS) for talaromycosis in non-HIV-infected patients by comparing mNGS with traditional microbial culture.
View Article and Find Full Text PDFBackground: Mucormycosis is a rare form of invasive, rapidly progressive and lethal opportunistic fungal infection caused by Mucorales. Although Rhizopus arrhizus (R. arrhizus) is the most commonly isolated Mucorales worldwide, infections caused by Apophysomyces variabilis (A.
View Article and Find Full Text PDFArticle Synopsis
- A thermally dimorphic fungus causes systemic mycoses and the study focuses on the combined use of berberine (BBR) and fluconazole (FLC) against FLC-resistant strains.
- The combination of BBR and FLC significantly lowers the minimum inhibitory concentration (MIC) from 256 μg/ml to 8 μg/ml, indicating a strong synergistic effect.
- Mechanisms behind the antifungal action include increased reactive oxygen species, reduced ergosterol content, disrupted cell integrity, and reduced expression of specific genes, suggesting BBR could effectively treat Talaromycosis.
Originally considered to be a plant pathogen, reports of phaeohyphomycosis due to () in animals and humans are increasing. However, studies on the pathogenesis, virulence, and epidemiology of have rarely been discussed. In the present study, BALB/c mice were experimentally inoculated with suspension by different routes and the course of infection was evaluated.
View Article and Find Full Text PDFIntroduction: Although pulsed dye laser (PDL) remains the gold standard for the treatment of port-wine stains (PWS), hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) is another treatment modality that has been shown to be effective in the treatment of PWS. This study aimed to observe the clinical efficacy and therapeutic response of HMME-PDT in the treatment of pediatric Chinese patients with PWS and to analyze the association between the efficacy of therapy and the dermoscopic features of PWS.
Methods: Pediatric patients with PWS and negative HMME skin test were enrolled between December 2017 and May 2021.
Article Synopsis
- * The child presented with a rapidly growing pigmented lesion on her palm, which was successfully treated with topical naftifine hydrochloride and ketoconazole cream.
- * This report is notable as it identifies C. lunata as the first documented pathogen for tinea nigra, and it includes a review of existing literature on various causes, characteristics, and treatments of the condition.
This study analyzed the drug sensitivity of spp. from Guangxi, Southern China. One hundred three strains of were recovered from 86 patients; 14 were HIV positive and 72 were HIV negative.
View Article and Find Full Text PDFBackground: In China, the prevalence of superficial fungal infections of the foot is high and recurrence is common. However, a prospective, large-scale and multicentre study on the aetiology of superficial fungal infections of the foot is still lacking.
Objectives: To study the epidemiology of aetiological agents of superficial fungal infections of the foot in urban outpatients in mainland China, as well as to understand the aetiology features of the pathogenic agent.
Talaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immunosuppression.
View Article and Find Full Text PDFis a common cause of infection in immunocompromised patients in Southeast Asia and Southern China. The pathogenicity of depends on the ability of the fungus to survive the cytotoxic processes of the host immune system and grow inside host macrophages. These mechanisms that allow to survive macrophage-induced death are poorly understood.
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- Limited knowledge exists about Talaromyces marneffei infection in children, prompting a retrospective study involving 11 HIV-negative pediatric patients.
- The study revealed a mortality rate of 36.36%, with many children having underlying diseases and significant immune system issues.
- Voriconazole was the primary treatment, showing positive results in most cases, while also highlighting the importance of recognizing this infection as a sign of severe immunodeficiencies in children.
Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes.
View Article and Find Full Text PDF[Relationship between pre-exposure prophylaxis and HIV infection: a meta-analysis].
Zhonghua Yu Fang Yi Xue Za Zhi
February 2013
Objective: To evaluate the effect on pre-exposure prophylaxis (PrEP) to prevent HIV infection in high risk populations.
Methods: A computerized literature searching had been carried out in PubMed, EMbase, Ovid, Web of Science, Science Direct, Wanfang, Tsinghua Tongfang database and related websites to collect relevant papers (from establishment to June 2012) with the key words of pre-exposure prophylaxis, HIV, AIDS, high risk populations, relative risk, reduction. All randomized controlled trials (RCT) papers about using single or compound antiretroviral drugs (ARVs) orally or topically before HIV exposure or during HIV exposure in high risk populations were enrolled.