The LDL Receptor-Related Protein 1: Mechanisms and roles in promoting Aβ efflux transporter in Alzheimer's disease.

The LDL Receptor-Related Protein 1(LRP1), a member of the Low-density Lipoprotein (LDL) receptor family, is a multifunctional cellular transporter and signaling receptor, this includes regulation of lipid metabolism, cell migration and signaling. Abnormal accumulation of amyloid beta (Aβ) in the brain is thought to be the main pathological change in Alzheimer's disease. By binding to a variety of ligands, LRP1 is involved in the internalization and degradation of Aβ, thereby affecting the course of Alzheimer's disease (AD).

Role of SLC5A2 polymorphisms and effects of genetic polymorphism on sodium glucose cotransporter 2 inhibitorsinhibitor response.

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by hyperglycaemia. T2DM is a highly heterogeneous polygenic disease. Due to genetic variation, variations in lifestyle and other environmental exposures, there are certain variations in the phenotype of T2DM patients.

Fair classification domain adaptation: A dual adversarial learning approach.

Modern machine learning (ML) models are becoming increasingly popular and are widely used in decision-making systems. However, studies have shown critical issues of ML discrimination and unfairness, which hinder their adoption on high-stake applications. Recent research on fair classifiers has drawn significant attention to developing effective algorithms to achieve fairness and good classification performance.

An investigation of the intention and reasons of senior high school students in China to choose medical school.

Background: Shortages of qualified health workers have been a global concern, especially in developing countries. China also faces this dilemma, which hinders the development of public health services. Senior high school students are a group who are considering their college majors and careers after graduation.

α-Hydroxy coordination of mononuclear vanadyl citrate, malate and S-citramalate with N-heterocycle ligand, implying a new protonation pathway of iron-vanadium cofactor in nitrogenase.

Unlike the most of α-alkoxy coordination in α-hydroxycarboxylates to vanadium, novel α-hydroxy coordination to vanadium(IV) has been observed for a series of chiral and achiral monomeric α-hydroxycarboxylato vanadyl complexes [VO(H2cit)(bpy)]·2H2O (1), [VO(Hmal)(bpy)]·H2O (2), [VO(H2cit)(phen)]·1.5H2O (3), [VO(Hmal)(phen)]·H2O (4), and [(Δ)VO(S-Hcitmal)(bpy)]·2H2O (5), [VO(H2cit)(phen)]2·6.5H2O (6), which were isolated from the reactions of vanadyl sulfate with α-hydroxycarboxylates and N-heterocycle ligands in acidic solution.

Formations of mixed-valence oxovanadiumV,IV citrates and homocitrate with N-heterocycle chelated ligand.

Dimeric mixed-valence oxovanadium citrate [V 2O 3(phen) 3(Hcit)].5H 2O ( 1) (H 4cit = citric acid, phen = 1,10-phenanthroline) was isolated from a weak acidic medium. It could be converted quantitatively into a tetrameric oxovanadium citrate adduct of 1,10-phenanthroline [V 2O 3(phen) 3(Hcit) 2(phen) 3O 3V 2].

N-heterocycle chelated oxomolybdenum(VI and V) complexes with bidentate citrate.

A 1,10-phenanthroline (phen) chelated molybdenum(VI) citrate, [(MoO2)2O(H2cit)(phen)(H2O)2] x H2O (1) (H4cit = citric acid), is isolated from the reaction of citric acid, ammonium molybdate and phen in acidic media (pH 0.5-1.0).