Synthesis, characterization, thermal stability, and in vitro and in vivo degradation study of polycaprolactone and polyglycolide block copolymers.

Biodegradable polymer materials are attractive in various biomedical applications. Herein, we report a block aliphatic copolymer, polycaprolactone--polyglycolide (PCL--PGA, denoted as PCLGA), and explored the polymer composition effect on the thermal and degradation behaviors. Three copolymers with different PCL/PGA weight ratios were obtained by a two-step ring opening polymerization.