Quest for the Vulnerable Atheroma: Carotid Stenosis and Diametric Strain--A Feasibility Study.

The Bernoulli effect may result in eruption of a vulnerable carotid atheroma, causing a stroke. We measured electrocardiography (ECG)-registered QRS intra-stenotic blood velocity and atheroma strain dynamics in carotid artery walls using ultrasonic tissue Doppler methods, providing displacement and time resolutions of 0.1 μm and 3.

Development of an interactive Coronary Doppler Vibrometry system for detection of coronary artery disease.

Coronary artery disease is a deadly and costly condition and represents an important public health issue globally. Coronary Doppler vibrometry (CDV), a new noninvasive coronary artery stenosis detection technique, showed encouraging results in our recent clinical study. However, the CDV system required lengthy offline data analysis, thus it did not provide any feedback during examination on the quality of data, not to mention analysis results.

Reducing registration error in cross-beam vector doppler imaging with position sensor.

Various vector Doppler methods have been proposed in the last several decades to overcome the Doppler angle dependency in both conventional spectral Doppler and color Doppler by measuring both the speed and direction of blood flow. However, they have not been adopted for routine use because most of them require specialized hardware, which is not available in commercial ultrasound systems. An alternative approach (cross-beam method) that uses color Doppler images obtained from different steered beam angles is more feasible, but there is error in registering multiple color Doppler images because they are not acquired simultaneously.

Continuous-wave Near-infrared Topography System and Its Clinical Application.

We developed a reflectance continuous-wave near-infrared spectroscopy topography system with multi-source and multi-detector sensor head. A single wavelength (808 nm) laser diode is used as the original light source. With different-measurement approach, we can reconstruct images representing the variety of cerebral blood volume in clinical applications.