Virtual Intrauterine Device Placement Training Improves Clinician Comfort.

Background And Objectives: Virtual intrauterine device (IUD) training options can improve clinician continuing education and patient IUD access. Our objective was to evaluate a virtual, hands-on IUD training for primary care clinicians.

Methods: Training sessions occurred via video conferencing and included didactic instruction on IUD eligibility, counseling, placement, and removal.

A southwestern grassroots community coalition of undocumented Mexican community members: A location for bridging resources and sociopolitical action.

The current nativist and ethnocentric policies and rhetoric put forward in the United States have compromised the safety of undocumented Hispanic/Latinx Americans. Many in these communities abstain from overt action toward change. Nonetheless, there are examples of community members who embrace the narrative "undocumented and unafraid.

Increasing HIV/AIDS knowledge among urban ethnic minority youth: Findings from a community-based prevention intervention program.

HIV (Human Immunodeficiency Virus)/AIDs (Acquired immunodeficiency syndrome) prevention and research are imperative. Prevention-intervention programming is minimal in low-income communities of color. Additional research is needed that uncovers points of support and prevention to increase HIV knowledge and awareness and limit new HIV infections among adolescents of color.

The brief sense of community scale: Testing dimensionality and measurement invariance by gender among Hispanic/Latinx youth.

Psychological sense of community is defined as feelings of belongingness and a shared belief that community members will meet one another's needs. Psychological sense of community has four dimensions: membership, influence, needs fulfillment, and emotional connection. In this study, multigroup confirmatory factor analysis was used to examine the first and second-order factor structure of the brief sense of community scale (BSCS) between male and female Hispanic/Latinx adolescents from an urban community (N = 947).

Psychological sense of community and motivation toward collective social change among community coalition members of color in the southwestern United States.

Drawing on McMillan and Chavis's psychological sense of community framework among southwestern community coalition members (N = 18), data were examined for narratives of how psychological sense of community and experiences of community manifest among coalition members. We were also interested in knowing how coalition members make meaning of social change. Findings illustrate that dimensions of psychological sense of community (e.

Hemoglobin switching in mice carrying the variant.

Haploinsufficiency for transcription factor KLF1 causes a variety of human erythroid phenotypes, such as the In(Lu) blood type, increased HbA2 levels, and hereditary persistence of fetal hemoglobin. Severe dominant congenital dyserythropoietic anemia IV (OMIM 613673) is associated with the KLF1 p.E325K variant.

The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.

Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been described. The KLF1 Nan variant, a single amino acid substitution (p.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

B-cell lymphoma 11A (BCL11A) downregulation in human primary adult erythroid progenitors results in elevated expression of fetal γ-globin. Recent reports showed that BCL11A expression is activated by KLF1, leading to γ-globin repression. To study regulation of erythropoiesis and globin expression by KLF1 and BCL11A in an in vivo model, we used mice carrying a human β-globin locus transgene with combinations of Klf1 knockout, Bcl11a floxed, and EpoR(Cre) knockin alleles.

Defective erythroid maturation in gelsolin mutant mice.

Background: During late differentiation, erythroid cells undergo profound changes involving actin filament remodeling. One of the proteins controlling actin dynamics is gelsolin, a calcium-activated actin filament severing and capping protein. Gelsolin-null (Gsn(-/-)) mice generated in a C57BL/6 background are viable and fertile.

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells.

The Sox6 transcription factor plays critical roles in various cell types, including erythroid cells. Sox6-deficient mice are anemic due to impaired red cell maturation and show inappropriate globin gene expression in definitive erythrocytes. To identify new Sox6 target genes in erythroid cells, we used the known repressive double Sox6 consensus within the εy-globin promoter to perform a bioinformatic genome-wide search for similar, evolutionarily conserved motifs located within genes whose expression changes during erythropoiesis.