Publications by authors named "Cantone Anna"
Parkinson's disease displays clinical heterogeneity, presenting with motor and non-motor symptoms. Heterogeneous phenotypes, named brain-first and body-first, may reflect distinct α-synuclein pathology starting either in the central nervous system or in the periphery. The immune system plays a prominent role in the central and peripheral pathology, with misfolded α-synuclein being placed at the intersection between neurodegeneration and inflammation.
View Article and Find Full Text PDFCurrently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. There is urgent need for a better understanding of how smoking influences antidiabetic treatment efficacy.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly population worldwide. Due to the multifactorial nature of the disease, involving impairment of cholinergic neurotransmission and immune system, previous attempts to find effective treatments have faced challenges. In such scenario, we attempted to investigate the effects of alpha-glyceryl-phosphoryl-choline (α-GPC), a cholinomimetic molecule, on neuroinflammation and memory outcome in the triple transgenic mouse model of AD (3xTg-AD).
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- The study investigates the effectiveness of high-sensitivity troponin I (TnI) levels in diagnosing myocardial infarction (MI) in patients with heart failure (HF), as traditional methods may be less reliable in this group.
- Data from 562 patients with suspected MI were analyzed, showing that while baseline TnI had moderate predictive capability for MI, the relative change in TnI levels was a much more accurate indicator.
- The findings suggest that monitoring TnI changes is crucial for MI diagnosis in heart failure patients, and baseline TnI accuracy can be affected by the severity of HF, highlighting the need for comprehensive evaluation including BNP levels.
Alzheimer's disease (AD), marked by cognitive impairment, predominantly affects the brain regions regulated by cholinergic innervation, such as the cerebral cortex and hippocampus. Cholinergic dysfunction, a key contributor to age-related cognitive decline, has spurred investigations into potential therapeutic interventions. We have previously shown that choline alphoscerate (α-GPC), a cholinergic neurotransmission-enhancing agent, protects from Aβ-mediated neurotoxicity.
View Article and Find Full Text PDFMultiple sclerosis (MS) is the most prevalent chronic autoimmune inflammatory- demyelinating disorder of the central nervous system (CNS). It usually begins in young adulthood, mainly between the second and fourth decades of life. Usually, the clinical course is characterized by the involvement of multiple CNS functional systems and by different, often overlapping phenotypes.
View Article and Find Full Text PDFThe European Medicine Agency (EMA) has defined Adverse Drug Reactions (ADRs) as "a noxious and unintended response to a medicine", not including poisoning, accidental, or intentional overdoses. The ADR occurrence differs based on the approach adopted for defining and detecting them, the characteristics of the population under study, and the research setting. ADRs have a significant impact on morbidity and mortality, particularly among older adults, and represent a financial burden for health services.
View Article and Find Full Text PDFBackground: The debate surrounding the efficacy of coronary physiological guidance compared with conventional angiography in achieving optimal post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) values persists.
Objectives: The primary aim of this study was to demonstrate the superiority of physiology-guided PCI, using either angiography or microcatheter-derived FFR, over conventional angiography-based PCI in complex high-risk indicated procedures (CHIPs). The secondary aim was to establish the noninferiority of angiography-derived FFR guidance compared with microcatheter-derived FFR guidance.
Article Synopsis
- Researchers are studying how cardiopulmonary exercise testing (CPET) can help doctors predict the health of patients with a heart disease called cardiac amyloidosis (CA).
- They found that two specific measurements from these tests—peak VO and VE/VCO slope—can show who might be at a higher risk of dying from the disease.
- The results suggest that using CPET could be really helpful for doctors in deciding how to treat patients with CA better, but more research with larger groups of people is needed to confirm their findings.
Cardiovascular disease (CVD) is a chronic condition driven by the complex interaction of different risk factors including genetics, lifestyle, environment, etc. which, differently from other pathologies, can be prevented. Treatment of CVD has been inconceivably successful but now it seems that it has reached a plateau suggesting that prevention is the way forward.
View Article and Find Full Text PDFBackground: Cardiac amyloidosis (CA) is primarily a restrictive cardiomyopathy in which the impairment of diastolic function is dominant. Despite this, the left ventricular ejection fraction (LVEF) may be depressed in the late stage of the disease, but it poorly predicts prognosis in the earlier phases and does not represent well the pathophysiology of CA. Many echocardiographic parameters resulted important diagnostic and prognostic tools in patients with CA.
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- - The treatment for transthyretin (TTR)-related cardiac amyloidosis involves both supportive therapies to manage complications and disease-modifying therapies aimed at stopping the production and accumulation of amyloid fibrils.
- - Various approaches include gene silencing techniques (like patisiran and inotersen), stabilizing the TTR protein to prevent fibril formation (like tafamidis), and targeting existing amyloid deposits using experimental antibody treatments.
- - Current research focuses on several stages of amyloid development, with gene editing technologies such as CRISPR being explored, while existing antibody therapies are still undergoing early clinical trials.
[Use of multimodality imaging for the diagnosis of aortic stenosis].
G Ital Cardiol (Rome)
October 2022
Aims: This meta-analysis aims to compare direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in the setting of left ventricular thrombosis (LVT).
Method And Results: We systematically searched MEDLINE, Cochrane Library, Biomed Central and Web of Science for trials comparing DOACs versus VKAs in the setting of LVT and reporting outcome data on thrombosis resolution, stroke and bleeding. Fourteen studies were finally selected.
Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver. As a result of gene mutations or as an ageing-related phenomenon, TTR molecules may misfold and deposit in the heart and in other organs as amyloid fibrils. Amyloid transthyretin cardiac amyloidosis (ATTR-CA) manifests typically as left ventricular pseudohypertrophy and/or heart failure with preserved ejection fraction and is an underdiagnosed disorder affecting quality of life and prognosis.
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- Some elderly patients with a serious heart problem called aortic stenosis also have a condition called ATTR amyloid cardiomyopathy.
- It's not completely clear why these two heart issues often happen together, but they might affect each other.
- Doctors can figure out if a patient has both conditions by looking at heart tests, and even if they do have both, they can still safely replace the heart valve if needed.