Best Practices to Quantify and Identify Particulate Matter on the Interior Surfaces of Single-Use Systems.

The manufacturing of a wide range of biopharmaceuticals, from antibodies and vaccines to cell-based therapies, increasingly takes place in single-use processing equipment. Manufactured in clean rooms and sealed and sterilized, single-use systems (SUSs) are ready-to-use and easily scalable. Controls in the "clean-build" manufacturing of SUSs reduce the probability of occurrence of particulate matter in SUSs.

Using a contralateral shoe lift to reduce gait deterioration during an offloading fast-walk setting in diabetic peripheral neuropathy: A comparative feasibility study.

Aims: Diabetic peripheral neuropathy (DPN) is a predictor of foot ulcers and leads to sedentary behaviour. This comparative study evaluated gait and feasibility of a 20-minute fast walk, at 40-60% of cardiopulmonary capacity, in individuals with DPN wearing an offloading boot and a contralateral shoe balancer.

Methods: Gait parameters were measured with inertial sensors on 32 individuals (group with DPN [n = 16], group with diabetes but without DPN [n = 9], and a group without diabetes/DPN [n = 7]).

Lower Limb Biomechanics During Drop-Jump Landings on Challenging Surfaces in Individuals With Chronic Ankle Instability.

Context: Individuals with chronic ankle instability (CAI) exhibit impaired lower limb biomechanics during unilateral drop-jump landings on a flat surface. However, lower limb biomechanical adaptations during unilateral drop-jump landings on more challenging surfaces, such as those that are unstable or inclined, have not been described.

Objective: To determine how unilateral drop-jump landing surfaces (flat, unstable, and inclined) influence lower limb electromyography, kinematics, and kinetics in individuals with CAI.

Musculoskeletal ultrasound for 3D bone modeling: A preliminary study applied to lumbar vertebra.

Background: There is no non-invasive in vivo method to assess intervertebral kinematics. Current kinematics models are based on in vitro bone reconstructions from computed tomography (CT)-scan imaging, fluoroscopy and MRIs, which are either expensive or deleterious for human tissues. Musculoskeletal ultrasound is an accessible, easy to use and cost-effective device that allows high-resolution, real-time imaging of bone structure.

Effectiveness of an exercise-based prehabilitation program for patients awaiting surgery for lumbar spinal stenosis: a randomized clinical trial.

Lumbar spinal stenosis is the most common reason for spine surgery in older adults, but the effects of prehabilitation on perioperative outcomes among these patients have not been investigated. This study aims to evaluate the effectiveness of a preoperative exercise-based intervention program compared with usual care on the improvement of clinical status, physical capacities and postoperative recovery of patients awaiting surgery for lumbar spinal stenosis. Sixty-eight participants were randomised to receive either a 6-week supervised exercise-based prehabilitation program or hospital usual care.

Lower limb biomechanics in individuals with chronic ankle instability during gait: a case-control study.

Background: Individuals with chronic ankle instability (CAI) exhibit many biomechanical changes to lower limbs during walking. However, only a few studies have investigated the differences in lower limb biomechanics of individuals with CAI compared to healthy controls using a comprehensive approach including kinematic, kinetic and electromyography (EMG) measures. Consequently, the theoretical framework explaining the biomechanical adaptations in individuals with CAI is mostly based on the results of studies including heterogenous methods and participants' specificities (e.

Effectiveness of saline water and lidocaine injection treatment of intractable plantar keratoma: a randomised feasibility study.

Background: An intractable plantar keratoma (IPK) is a conical thickening of the epidermis' stratum corneum and a common cause of foot pain which can have a significant, detrimental impact on the mobility, quality of life and independence of individuals. Conservative treatments are currently offered to patients with IPK, but they are unsatisfactory since they do not offer a sufficient or permanent reduction of symptoms. The purpose of this study was the evaluation of the feasibility, safety and effectiveness of innovative treatments for intractable plantar keratoma (IPK).

Biomechanical effects of foot orthoses with and without a lateral bar in individuals with cavus feet during comfortable and fast walking.

Background/purpose: The biomechanical effects of foot orthoses (FOs) with and without a lateral bar compared to a control condition during walking at different speeds are still unknown. The objective of this study was to compare the biomechanical effects of functional FOs with and without a lateral bar to a control condition during comfortable walking in individuals with cavus feet and determine if their effects change at a fast speed.

Methods: Fifteen individuals with cavus feet (age: 25.

Impact of load expectations on neuromuscular and postural strategies during a freestyle lifting task in individuals with and without chronic low back pain.

Objective: This study aimed to investigate how load expectations modulate neuromuscular and postural strategies in the anticipation of a freestyle lifting task with varying expected loads in individuals with and without chronic low back pain (cLBP).

Methods: Forty-seven participants, 28 with cLBP pain and 19 without, were recruited and completed a series of freestyle lifting trials (3 sets of box lifted for a total of 36 lifts). Verbal cues were used to modulate their expectations about the boxes' weight: no expectation, lighter or heavier load expectations.

The influence of footwear on walking biomechanics in individuals with chronic ankle instability.

Background/purpose: The effects of footwear on the walking kinematics, kinetics and electromyography (EMG) of individuals with chronic ankle instability (CAI) at different speeds are still unknown. The objective of this cross-sectional study was to evaluate the kinematic, kinetic and electromyography differences between shod and barefoot walking at comfortable (CW) and fast (FW) speeds in individuals with CAI.

Methods: Twenty-one individuals with CAI walked on a 5-meter walkway shod and barefoot at CW and FW speeds.

Kinematic, kinetic and electromyographic differences between young adults with and without chronic ankle instability during walking.

The objective of this study was to quantify the kinematic, kinetic and electromyography differences between individuals with and without chronic ankle instability (CAI) during comfortable (CW) and fast (FW) walking. Twenty-one individuals with CAI and 21 healthy controls were recruited to walk at CW and FW speeds. The dependent variables were gluteus medius, vastus lateralis, gastrocnemius lateralis, gastrocnemius medialis, peroneus longus and tibialis anterior muscles mean activity, ankle and knee angles and moments.

Unilateral jump landing neuromechanics of individuals with chronic ankle instability.

Objectives: To assess the neuromechanical (kinematic, kinetic and electromyographic (EMG)) differences between individuals with and without chronic ankle instability (CAI) during unilateral jump landing.

Design: Case-control study.

Methods: Kinematic, kinetic and EMG data of 32 participants with CAI and 31 control participants were collected during unilateral side jump landing (SIDE) and unilateral drop landing on three surfaces (even (DROP), unstable (FOAM) and laterally inclined (WEDGE)).

Effects of foot orthoses on walking and jump landing biomechanics of individuals with chronic ankle instability.

Objectives: To evaluate the kinematic, kinetic and electromyographic (EMG) immediate effects of foot orthoses (FOs) during walking, maximal single-leg side jump landing (SIDE) and unilateral drop landing on even (DROP), inclined and unstable (FOAM) surfaces in individuals with chronic ankle instability (CAI).

Design: Cohort study.

Setting: Biomechanics laboratory.

Feasibility of conducting an active exercise prehabilitation program in patients awaiting spinal stenosis surgery: a randomized pilot study.

Prehabilitation is defined as the process of augmenting functional capacity before surgery in preparation for the postoperative phase. This study intends to assess the feasibility of conducting a preoperative intervention program in patients with lumbar spinal stenosis and to report on the piloting of the proposed intervention. Patients were allocated to a 6-week supervised preoperative rehabilitation program or a control group.

Effect of Massage on Clinical and Physiological Variables During Muscle Fatigue Task in Participants With Chronic Low Back Pain: A Crossover Study.

Objective: The purpose of this study was to determine if a reduction of short-term physiological and clinical effects of muscle fatigue can be seen after a session of massage in nonspecific chronic low back pain (cLBP) individuals and to study the possible association between physiological and clinical changes induced by massage.

Methods: Thirty-six cLBP individuals participated in 2 experimental sessions. In one session, the Sorenson protocol was preceded by a 30-minute massage, but in the other session, only the Sorenson test was performed by participants.

Muscle activation during fast walking with two types of foot orthoses in participants with cavus feet.

The aim of this study was to quantify the effects of foot orthoses (FOs) with and without a lateral bar on muscle activity of participants with cavus feet. Fifteen participants were recruited from the Université du Québec à Trois-Rivières students and podiatry clinic. The muscle activity of the tibialis anterior, fibularis longus, gastrocnemius lateralis and medialis, vastus medialis and lateralis, biceps femoris and gluteus medius were recorded during fast walking under two experimental conditions (FOs with and without a lateral bar) and a control condition (shoes).

Predictors of disability and absenteeism in workers with non-specific low back pain: A longitudinal 15-month study.

Objectives: The objective of this study was to identify baseline predictors of disability and absenteeism in workers with a history of non-specific low back pain (LBP).

Methods: One hundred workers with a history of non-specific LBP participated in three evaluations (baseline, 7 and 15 months follow-up). Current and past history of LBP, clinical pain intensity, disability, absenteeism, fear-avoidance beliefs, pain catastrophizing, pain hypervigilance, work satisfaction and patient stratification based on "risk of poor clinical outcome assessment" (RPCO) were evaluated using questionnaires and interviews.

Contribution of Load Expectations to Neuromechanical Adaptations During a Freestyle Lifting Task: A Pilot Study.

Objectives: The main goal of this study was to determine to what extent load expectations modulate neuromechanical adaptations in individuals with and without chronic low back pain (cLBP) when lifting and lowering various loads. The second goal was to assess the feasibility of a simple lifting protocol during which expectations about loads were manipulated.

Methods: Seventeen participants with cLBP and 18 participants without low back pain were asked to lift and lower boxes of mild to moderate loads.

Effects of chronic ankle instability on kinetics, kinematics and muscle activity during walking and running: A systematic review.

The aim of this study is to systematically review and appraise studies assessing the effects of chronic ankle instability (CAI) on kinetics, kinematics and muscle activity during walking and running. The primary search was conducted in PubMed, Embase, CINAHL, AMED and SPORTDiscus. Only studies that compared participants with CAI with healthy participants and assessed kinetics, kinematics or muscle activity during walking or running were included.

Physiological and Psychological Predictors of Short-Term Disability in Workers with a History of Low Back Pain: A Longitudinal Study.

Despite an elusive pathophysiology, common characteristics are often observed in individuals with chronic low back pain (LBP). These include psychological symptoms, altered pain perception, altered pain modulation and altered muscle activation. These factors have been explored as possible determinants of disability, either separately or in cross-sectional studies, but were never assessed in a single longitudinal study.

Effects of two types of foot orthoses on lower limb muscle activity before and after a one-month period of wear.

The purpose of this study was to quantify the effects of two types of foot orthoses (FOs) on muscle activity during walking. Twenty-one healthy participants were recruited to walk on a five-meter walkway with a control condition (no FOs) and two experimental conditions (FOs and FOs with lateral bar). The experimental protocol was performed before and after a one-month period of wear for each experimental condition.

Effects of a prehabilitation program on patients' recovery following spinal stenosis surgery: study protocol for a randomized controlled trial.

Background: Degenerative lumbar spinal stenosis is a prevalent condition in adults over the age of 65 and often leads to deconditioning. Although the benefits of surgery outweigh those of conservative approaches, physical rehabilitation may be used to improve function and to minimize the risk of persistent dysfunction. This study protocol was designed to establish the feasibility of a full-scale randomized controlled trial and to assess the efficacy of an active preoperative intervention program on the improvement of clinical parameters and functional physical capacity in patients undergoing surgery for lumbar spinal stenosis.

Musculoskeletal symptoms in an adolescent athlete population: a comparative study.

Background: Musculoskeletal pain, symptoms or injuries are prevalent in the adolescent athlete population as well as in the general adolescent population, and often have significant consequences on their future musculoskeletal health. However, differences between these two populations in regards to their musculoskeletal health are not known and have not yet been explored. Therefore, the main objectives of this study are to 1) compare the 6-month prevalence of musculoskeletal symptoms and their impact on school attendance and reduction in sport or leisure activity between a group of adolescent athletes and a group of control adolescents, and 2) determine if gender has different effects on the prevalence of musculoskeletal symptoms in these two populations.

Changes implemented during a workplace psychosocial intervention and their consistency with intervention priorities.

Objectives: To describe the changes implemented as part of a workplace psychosocial intervention.

Methods: The intervention was conducted in a public organization employing 1630 white-collar workers. The intervention was defined as all changes implemented to reduce adverse psychosocial work factors.

Use of hyaluronic acid gel filler versus sterile water in the treatment of intractable plantar keratomas: a pilot study.

Background: Intractable plantar keratoma is a common concern in the podiatric medical office. Different treatment options are available, ranging from trimming and padding to surgery. We sought to investigate the use of hyaluronic acid gel injections as a possible minimally invasive alternative in the treatment of intractable plantar keratomas.