Publications by authors named "Cansu Babahan"
Background/aim: The role of PD-L1 in regulating the immunosuppressive tumor microenvironment via its binding on PD-1 receptors is extensively studied. The PD-1/PD-L1 axis is a significant way of cancer immune escape, and PD-L1 expression on tumor cells is suggested as a predictive marker for anti-PD-1/PD-L1 monoclonal antibodies (MoAbs). However, the tumor-intrinsic role of PD-L1 is not known well.
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- Adenoviral vectors (AV) are popular for vaccines and gene therapy due to their easy production, ability to grow in large quantities, and safety for human use, but their efficiency varies.
- This study examined how different downstream treatment protocols and microfiltration methods affect the yield of viral vectors, specifically comparing the repeated freeze-thaw (RFT) and Tween-20 detergent lysis (DLT) methods.
- Results indicated that a 2-hour incubation at 37 °C with Tween-20 proved optimal for virus recovery, while a 4-hour incubation at room temperature is also viable, leading to the initiation of a phase 1 clinical trial for the recombinant adenovirus studied.
Article Synopsis
- Cancer stem cells (CSCs) are a unique group within tumors that can self-renew and cause treatment resistance, leading to relapse.
- Conventional therapies often miss CSCs, but new research shows that targeting them could improve cure rates through various methods, including modified chemotherapy and small molecule inhibitors.
- Innovative approaches like dendritic cell vaccines combined with immune-checkpoint inhibitors and oncolytic viruses are being explored as effective strategies to specifically target and eliminate CSCs.