Publications by authors named "Canliang Tan"
Article Synopsis
- Cholangiocarcinoma (CCA) is a severe cancer with few treatment options, and the study focuses on the role of Platelet-Derived Growth Factor CC (PDGF-CC) in its progression.
- Researchers compared PDGF-CC levels in CCA and normal tissues and found elevated mRNA and protein levels in CCA, linking high PDGF-CC expression to worse survival rates for patients.
- By depleting PDGF-CC in various cell lines and using xenograft models, the study demonstrated that reducing PDGF-CC leads to decreased cancer cell growth and suggests that targeting PDGF-CC could be a promising therapeutic approach for CCA.
Background: Zinc finger E-box binding homEeobox 1 (ZEB1) and ZEB2 are two anoikis-related transcription factors. The mRNA expressions of these two genes are significantly increased in kidney renal clear cell carcinoma (KIRC), which are associated with poor survival. Meanwhile, the mechanisms and clinical significance of ZEB1 and ZEB2 upregulation in KIRC remain unknown.
View Article and Find Full Text PDFMicroRNA-361-5p (miR-361-5p) is a tumor suppressor miRNA that is dysregulated in several types of human cancer. However, the functional significance of miR-361-5p in hepatocellular carcinoma (HCC) is unclear. This study explored the biological function of miR-361-5p in regulating the progression of HCC and the underlying molecular mechanism.
View Article and Find Full Text PDFDistant metastasis is the primary barrier for the successful treatment of patients with colorectal cancer, and thus, searching for new therapeutic targets by further exploring the molecular mechanisms of colorectal cancer metastasis is important. In this study, we investigated the biological and clinical significance of RASSF6 in colorectal cancer as well as the underlying molecular mechanisms. We found that low RASSF6 expression corresponds to a poor prognosis in colorectal cancer patients, and low RASSF6 expression is distinctly associated with tumour progression.
View Article and Find Full Text PDFThe aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α in the tumor tissue of patients with invasive ductal carcinoma(IDC); in addition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who were not previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III.
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