Component-specific, cigarette particle deposition modeling in the human respiratory tract.

Inhalation of cigarette smoke particles (CSP) leads to adverse health effects in smokers. Determination of the localized dose to the lung of the inhaled smoke aids in determining vulnerable sites, and identifying components of the smoke that may be responsible for the adverse effects; thus providing a roadmap for harm reduction of cigarette smoking. A particle deposition model specific to CSP was developed for the oral cavity and the lung by accounting for cigarette particle size growth by hygroscopicity, phase change and coagulation.

Relaxation times in single event electrospraying controlled by nozzle front surface modification.

Single event electrospraying (SEE) is a method for on-demand deposition of femtoliter to picoliter volumes of fluids. To determine the influence of the size of the meniscus on the characteristics of the single event electrospraying process, glass capillaries were used with and without an antiwetting coating comprising a self-assembled 1H,1H,2H,2H-perfluorodecyltrichlorosilane-based monolayer to control the meniscus size. A large difference was found in driving single event electrospraying from a small meniscus compared to what is needed to generate a single event electrospraying from a large meniscus.