Publications by authors named "Candy B More"
Article Synopsis
- The study aims to assess the therapeutic potential of vitamin D receptor (VDR) signaling in adrenocortical carcinoma (ACC) cells, specifically H295R.
- Researchers found that VDR was hypermethylated and underexpressed in these cells, but treatments with calcitriol and seocalcitol restored VDR signaling, reduced cell proliferation, and affected other signaling pathways.
- In animal models, seocalcitol inhibited tumor growth and reduced steroid secretion from tumors without severe side effects, suggesting VDR could be a promising target for ACC therapy and patient management.
Article Synopsis
- Pediatric adrenocortical tumors (pACT) show complex genomic profiles and lack clear prognostic markers and treatment options, prompting research into the Vitamin D3 receptor (VDR) for potential insights.
- A study involving 108 pediatric patients found that most pACT had low VDR expression and high methylation, particularly in more aggressive carcinomas, suggesting a link between VDR status and disease severity.
- The findings indicate that VDR hypermethylation and underexpression could serve as important predictive and prognostic biomarkers for pACT, affecting patient outcomes.
Objective: To investigate the impact of early exposure to androgen excess on gonadotropin-dependent puberty (GDP) and final height (FH) of patients with androgen-secreting adrenocortical tumors (ACT) in childhood.
Methods: Retrospective cohort study. Occurrence of GDP and achievement of FH were evaluated.