Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination.

Background: Alcohol-related responses are under strong genetic regulation. A wealth of alcohol-related data from recombinant inbred (RI) mouse strains enables genetic correlation and mapping of these traits. Previous studies using RI strains have identified numerous chromosomal locations that underlie differential alcohol sensitivity, although the regions identified are typically large.