Metabolic parameters in smokers undergoing smoking reduction.

Introduction: Few human studies have explored the mechanisms of smoking-induced insulin resistance. : To prospectively examine the metabolic changes of smoking reduction.

Methods: Cigarette smokers (n = 22; ½-2 packs per day) were enrolled in a smoking reduction program (counseling plus bupropion × 8 weeks; Phase I) followed by monitoring only (no counseling or bupropion × 16 weeks; Phase II).