Publications by authors named "Candelaria O'Farrell"
Article Synopsis
- Candida species are a leading cause of invasive fungal diseases, particularly affecting children with blood cancers; the study found that non-albicans Candida (NAC), especially C. tropicalis, are linked to worse outcomes in these patients.* -
- Researchers reviewed data from 53 patients over a decade and discovered a high incidence rate of invasive candidiasis (IC) and a significant link between C. tropicalis infections and dissemination to various organs, including the eyes and skin.* -
- The study highlights the importance of eye examinations in patients with IC, revealing that a notable percentage showed evidence of intraocular candidiasis, and emphasizes the need for further research to refine screening strategies for at-risk patients.*
Article Synopsis
- Researchers conducted a genome-wide association study to identify genetic variants linked to pediatric immune thrombocytopenia (ITP) in a large group of patients.
- Six significant genetic variants were found, particularly in the genes NAV2 and NKD1, which are associated with the Wnt signaling pathway and inversely correlated with ITP.
- The study highlighted that no significant genetic variants were found to differentiate between those with ITP who recovered quickly and those who developed chronic ITP, suggesting a complex genetic influence on disease outcomes.
Article Synopsis
- Crohn's disease is an inflammatory bowel disease that can affect various parts of the body, not just the gastrointestinal tract, and its symptoms can appear at different times.
- The report details a case of a 16-year-old boy who developed a stubborn rash in specific areas of the body, which turned out to be linked to Crohn's disease.
- After experiencing gastrointestinal symptoms, he was diagnosed with Crohn's disease, and his skin lesions improved after being treated with a medication called adalimumab.
Fibrinogen replacement therapy is a treatment mainstay for patients with afibrinogenemia and significant bleeding. A male infant with congenital afibrinogenemia and several spontaneous hemarthroses commenced cryoprecipitate prophylaxis but developed severe urticarial reactions. He transitioned to a human fibrinogen concentrate (HFC) (RiaSTAP , CSL Behring; 70 mg/kg biweekly) but continued experiencing hemarthroses (estimated annualized bleeding rate [ABR]: 5-6) and severe anaphylactic reactions, despite pre- and postinfusion medications.
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