The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis.

Background: Curcumin is an antioxidant and anti-inflammatory molecule known to be a potent inhibitor of nuclear factor kappa B (NF-kappa B). In this study, we aimed to investigate the therapeutic effects of curcumin on colitis induced by a 2,4,6-trinitrobenzene sulfonic acid (TNBS).

Methods: After the induction of colitis under anesthesia, 42 rats were divided into six groups as follows; the curcumin oral group, curcumin (20 mg/kg); the corn oil oral group, corn oil (20 mg/kg) using gastric gavage, the curcumin rectal group, curcumin; the corn oil rectal group, corn oil; the control group, 1 mL saline solution (0.

A comparison of the quantitative evaluation of in situ parathyroid gland perfusion by indocyanine green fluorescence angiography and by visual examination in thyroid surgery.

Objective The most vital complications of thyroidectomy are recurrent nerve damage and hypocalcaemia. We aimed to compare the tissue perfusion scores (PS) of IG fluorescence angiography (IGFA) and visual examination by the surgeon after total thyroidectomy. Subjects and methods Forty-three patients were accepted into the study.

Impact of Photobiomodulation on T3/T4 Ratio and Quality of Life in Hashimoto Thyroiditis.

Hashimoto's thyroiditis (HT) is both a B cell- and T cell-mediated, organ-specific autoimmune disease. No current treatment for underlying pathological mechanisms is available for HT and once diagnosed it requires long-term levothyroxine (LT) treatment in most patients. The aim of our study was to evaluate the effects of photobiomodulation (PBM) on HT patients regarding thyroid functions, thyroid autoantibody levels, and decrease in hormone replacement needs.

Intraoperative nerve monitoring is useful for surgical training in thyroid surgery.

Objective: Parathyroid glands and recurrent laryngeal nerves (RLNs) are at risk during thyroid surgery. However, the identification of the nerves reduced these risks. Intraoperative nerve monitoring (IONM) during thyroid surgery has gained widespread acceptance as an aid to the gold standard of visually identifying the RLN.

Is intraoperative nerve monitoring useful for surgical training in thyroid surgery?

Objectives: Parathyroid glands and recurrent laryngeal nerves (RLNs) are at risk during thyroid surgery. However, the identification of the nerves has reduced these risks. Intraoperative nerve monitoring (IONM) during thyroid surgery has gained widespread acceptance as an aid to the gold standard of visually identifying the RLN.

Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats.

Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP).

Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis.

Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group.

Role of diclofenac sodium and paracetamol on colonic anastomosis: An experimental rodent model.

Background: Despite many advances in surgery and technology, colonic anastomosis remains a challenge after colonic resection. The purpose of this study is to compare the safety of using diclofenac sodium and paracetamol for analgesia in colonic anastomosis on rats.

Methods: Wistar-Hannover rats were randomly allocated to four groups: Group 1, sham-operated group; Group 2, control group; Group 3, diclofenac sodium group; Group 4, paracetamol group.

Primary squamous cell carcinoma of the stomach.

Primary squamous cell carcinoma of the stomach accounts for less than 1% of all gastric malignancies. Less than 100 cases were reported in the literature. Therefore, knowledge about management and prognosis of the disease is limited.

Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model.

Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes.

Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats.

Obstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic effects of nesfatin-1 on OJ in rats.

Metastatic gastric signet-ring cell carcinoma: A rare cause of acute appendicitis.

We report a 32-year-old patient who underwent laparoscopy with classical symptoms and signs of acute appendicitis. An inflamed, edematous and non-perforated appendix, also a large amount gelatinous ascites, omental and peritoneal implants were seen. Appendectomy was performed and multiple biopsies were taken from omentum and peritoneum for definitive diagnosis.

Lithium-associated primary hyperparathyroidism complicated by nephrogenic diabetes insipidus.

Lithium-associated hyperparathyroidism is the leading cause of hypercalcemia in lithium-treated patients. Lithium may lead to exacerbation of pre-existing primary hyperparathyroidism or cause an increased set-point of calcium for parathyroid hormone suppression, leading to parathyroid hyperplasia. Lithium may cause renal tubular concentration defects directly by the development of nephrogenic diabetes insipidus or indirectly by the effects of hypercalcemia.

Isolated thyroid metastasis from renal cell carcinoma.

Metastatic neoplasms of the thyroid are uncommon when compared to primary tumors of the gland. Renal cell carcinoma (RCC) is a highly aggressive tumor of the urinary system. It can spread all over the body.

Survival effect of supportive care services for Turkish patients with metastatic gastric cancer.

Background: Gastric cancer is the second most common cause of cancer- related deaths worldwide and ranks 11th or 14th among all deaths. Patients with advanced disease require supportive care along with the medical and/ or surgical treatment.

Aim: To assess the need for palliative care for patients with advanced tumours along with standard clinical therapy.

Abdominal cocoon syndrome is a rare cause of mechanical intestinal obstructions: a report of two cases.

Background: Abdominal cocoon syndrome is also known in the literature as sclerosing peritonitis or sclerosing encapsulating peritonitis. It is characterized by total or partial encapsulation of abdominal viscera by a fibrous membrane. It has been reported mainly in adolescent women and the majority of the cases are of unknown etiology.

Hepatic hydatid disease requiring urgent treatment during pregnancy.

Background: Pregnant women may experience an acute presentation of hepatic hydatid disease. The available literature is limited to case reports.

Methods: The charts of 7 patients who underwent urgent treatment for hepatic hydatid disease during pregnancy between 1992 and 2010 were reviewed.

Novel hemostatic devices in thyroid surgery: are they necessary in every patient performing thyroidectomy?

TThis study was conducted to compare the outcome of total thyroidectomy using novel hemostatic devices and the classic suture ligation technique. This prospective study included 195 consecutive patients undergoing total thyroidectomy between January 2008 and March 2009. The main outcomes measured were operating time, intraoperative blood loss, postoperative drainage, pain score, and postoperative complications.

Primary retroperitoneal hydatid disease mimicking retroperitoneal malignant tumor.

Background: Hydatid disease (HD) is endemic in many parts of the world. It may develop in almost any part of the body; the liver is the organ most frequently involved. HD in an unusual location may make differential diagnosis difficult.