Tuning Compressive Young's Moduli and Antibacterial Activities of Alginate/Poly(-isopropylacrylamide) Hydrogels with Laponite Layers and Cerium Ions.

Hybrid hydrogels containing alginate (Alg) and poly(-isopropylacrylamide) (PNIPAAm) chains as natural and synthetic components, respectively, were crosslinked using double and triple pairs of the crosslinkers Ce/Ce, laponite (LP) RD, and ,'-methylenebisacrylamide (BIS). (Alg/PNIPAAm)-Ce and (Alg/PNIPAAm-PNIPAAm)-Ce double- and triple-network structures were prepared using multivalent cerium ions (Ce), multifunctional laponite layers (L), and/or neutral tetrafunctonal BIS molecules (B). Compressive Young's moduli, E, were tuned by the type/concentration of crosslinkers and crosslinking procedures and the concentration of Alg chains.

Improved mechanical properties of antimicrobial poly(-[3-(dimethylaminopropyl)] methacrylamide) hydrogels prepared by free radical polymerization in the presence of cetyltrimethylammonium bromide as a lyotropic liquid crystal template.

The poor mechanical strength of the poly(-[3-(dimethylamino)propyl] methacrylamide) (PDMAPMAAm) hydrogel limits its application as a drug delivery system and antimicrobial agent. In this study, both its morphology and antibacterial effectiveness were controlled through free radical solution polymerization in the presence of cetyltrimethylammonium bromide (CTAB; cationic nonreactive surfactant), forming lyotropic liquid crystal (LLC) mesophases. All the templated reactions proceeded in four different CTAB concentrations with three different concentrations of DMAPMAAm (2.

Study on preparation, compression strength and theophylline/diclofenac sodium release ability of NIPAAm/DMAPMAAm hydrogels.

The present study was undertaken to investigate the effect of the composition of the polymerization medium and the type of drug/drug loading process on the mechanical strengths and release profiles of poly(N-isopropylacrylamide-co-N-[3-(dimethylamino)propyl] methacrylamide) P(NIPAAm-co-DMAPMAAm) hydrogels. In line with this goal firstly, the temperature- and pH-responsive hydrogels of NIPAAm and DMAPMAAm were synthesized in three different media at 60 °C: pH 7.4 phosphate-buffered saline (PBS), pH 7.