Data Collection and Harmonization in HIV Research: The Seek, Test, Treat, and Retain Initiative at the National Institute on Drug Abuse.

Large-scale, multisite data sets offer the potential for exploring the public health benefits of biomedical interventions. Data harmonization is an emerging strategy to increase the comparability of research data collected across independent studies, enabling research questions to be addressed beyond the capacity of any individual study. The National Institute on Drug Abuse recently implemented this novel strategy to prospectively collect and harmonize data across 22 independent research studies developing and empirically testing interventions to effectively deliver an HIV continuum of care to diverse drug-abusing populations.

CCA1 and ELF3 Interact in the control of hypocotyl length and flowering time in Arabidopsis.

The circadian clock is an endogenous oscillator with a period of approximately 24 h that allows organisms to anticipate, and respond to, changes in the environment. In Arabidopsis (Arabidopsis thaliana), the circadian clock regulates a wide variety of physiological processes, including hypocotyl elongation and flowering time. CIRCADIAN CLOCK ASSOCIATED1 (CCA1) is a central clock component, and CCA1 overexpression causes circadian dysfunction, elongated hypocotyls, and late flowering.

The Jumonji C domain-containing protein JMJ30 regulates period length in the Arabidopsis circadian clock.

Histone methylation plays an essential role in regulating chromatin structure and gene expression. Jumonji C (JmjC) domain-containing proteins are generally known as histone demethylases. Circadian clocks regulate a large number of biological processes, and recent studies suggest that chromatin remodeling has evolved as an important mechanism for regulating both plant and mammalian circadian systems.

The psychosocial burden of HPV: a mixed-method study of knowledge, attitudes and behaviors among HPV+ women.

Despite an increased awareness and 'normalization' of Human Papillomavirus (HPV) following the release of the HPV vaccine, the psychosocial impact of an HPV infection, the most common sexually transmissible infection (STI), must not be overshadowed. This study employed in-depth interviews (N = 52) and quantitative surveys (N = 154) to assess the knowledge, emotional impact and behavioral consequences of an HPV-related diagnosis in women who had received abnormal Pap test results. Findings revealed confusion over test results and themes related to stigma, fear, self-blame, powerlessness and anger emerged.

HPV knowledge among HPV+ women.

Objective: To assess knowledge and information seeking among women recently receiving an HPV+ diagnosis.

Methods: A 2-phase mixed methods design was used. In both phase I (qualitative) and phase II (quantitative), women with scheduled gynecological exams and Pap smears at clinic sites were approached to participate.

Isolation of a novel family of genes related to 2-oxoglutarate-dependent dioxygenases from soybean and analysis of their expression during root nodule senescence.

A screen for genes involved in root nodule senescence has led to the isolation of the senescence-associated nodulin 1 (SAN1) multigene family from Glycine max (soybean). The three, tandemly repeated SAN1 genes each have three exons and two introns and are highly conserved. SAN1A and SAN1B code for conceptual proteins of 352 and 353 amino acids, respectively, and share over 83% sequence identity, while SAN1C encodes a truncated protein of 126 amino acids and is likely to be a pseudogene.