Publications by authors named "Candace M Murray"
Article Synopsis
- Scientists wanted to see if a receptor called CXCR2 causes damage during a Chlamydia infection, which can lead to problems like infertility.
- They tested mice with different CXCR2 genes to see how their bodies reacted to the infection.
- They found that mice without CXCR2 had less damage and inflammation after the infection, suggesting that CXCR2 makes the damage worse but isn't needed to fight off the infection itself.
Vigorous acute inflammatory responses accompany Chlamydia muridarum infections in mice and are positively correlated with adverse urogenital and respiratory tract infection outcomes in the mouse model. Thus, we tested the hypothesis that neutrophils induce an acute inflammatory insult that, in the repair phase, leads to the chronic sequelae of hydrosalpinx - a surrogate marker of infertility in the mouse model. To this end, we induced neutropenia in mice using a neutrophil-depleting monoclonal antibody during acute phases of C.
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