Publications by authors named "Candace L Barr"
Separate and shared sympathetic outflow to white and brown fat coordinately regulates thermoregulation and beige adipocyte recruitment.
Am J Physiol Regul Integr Comp Physiol
January 2017
Article Synopsis
- White adipose tissue (WAT) and brown adipose tissue (BAT) are influenced by the sympathetic nervous system (SNS), but it’s unclear if they share the same SNS pathways for regulation.
- Researchers injected a virus to trace SNS pathways in Siberian hamsters, finding more SNS neurons connecting to BAT than to WAT, but with significant crossover between the two across different brain regions.
- Experiments on denervated hamsters showed that they maintained body temperature in cold conditions and that their WAT showed signs of enhanced metabolic activity and beige fat development, indicating a functional connection between WAT and BAT through SNS pathways for regulating thermoregulation.