Publications by authors named "Candace E Cuthbert"
Article Synopsis
- Mayaro virus (MAYV) causes febrile illnesses similar to chikungunya virus (CHIKV) and poses a public health risk despite sporadic outbreaks.
- Pre-exposure to CHIKV, either through infection or vaccination, offers significant cross-protection against MAYV in mice, while other alphavirus or flavivirus immunities do not.
- Neutralizing antibodies, rather than T-cells, are key in providing this protective effect, and human sera from CHIKV infections can also neutralize MAYV, suggesting CHIKV infection may help limit MAYV emergence.
A maternal high-fat, high-sucrose (HFS) diet alters offspring glucose and lipid homoeostasis through unknown mechanisms and may be modulated by folic acid. We investigated the effect of a maternal HFS diet on glucose homoeostasis, expression of genes and proteins associated with insulin signalling and lipid metabolism and the effect of prenatal folic acid supplementation (HFS/F) in male rat offspring. Pregnant Sprague-Dawley rats were randomly fed control (CON), HFS or HFS/F diets.
View Article and Find Full Text PDFBackground: The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. This study examined whether these variants are associated with anthropometry at birth among a representative multi-ethnic sample of Trinidadian neonates.
Methods: Cord blood was obtained from consecutive term live births and DNA was genotyped for FTO and PPARG2 variants using polymerase chain reaction.