Augmented type 2 inflammatory response in allergic rhinitis patients experiencing systemic reactions to house dust mite subcutaneous immunotherapy.

Background: Subcutaneous immunotherapy (SCIT) can induce systemic reactions (SRs) in certain patients, but the underlying mechanisms remain to be fully elucidated.

Methods: AR patients who were undergoing standardized HDM SCIT (Alutard, ALK) between 2018 and 2022 were screened. Those who experienced two consecutive SRs were included in the study group.

A new isopimarane-type diterpene with anti-inflammatory activity from the .

A new isopimarane-type diterpene clinacanoid A () together with seven known terpenoids () were obtained from the . Their structures were elucidated based on extensive spectroscopic analysis (NMR, HR-ESI-MS), and the absolute configuration of was established based on single crystal X-ray diffraction. The inhibitory activity of all the compounds on NO production in lipopolysaccharide-induced (LPS) mouse leukemic monocyte macrophage RAW264.

Anxiety and depression in allergic rhinitis patients during COVID-19 pandemic in Wuhan, China.

Background: During COVID-19 pandemic, many allergic rhinitis (AR) patients stopped their treatment including pharmacotherapy and allergen immunotherapy.

Objective: This study aimed to investigate the anxiety and depression and general effect of COVID-19 pandemic on AR patients' psychological status in Wuhan, China.

Methods: In October 2019, 222 outpatients suffering from AR in our department and 133 healthy controls were enrolled.

Activation of TGF-β1 Pathway by SCUBE3 Regulates TWIST1 Expression and Promotes Breast Cancer Progression.

Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3) has been found to be associated with the development of several cancers. However, the biological role of SCUBE3 in breast cancer progression has not been reported. Western blotting and quantitative real-time polymerase chain reaction were used to measure the expressions of SCUBE3, TGF-β (transforming growth factor-β) signaling pathway markers, and epithelial-mesenchymal transition markers.