Publications by authors named "Cancan Jia"

Article Synopsis
  • The study introduces a next-generation sequencing (NGS) assay for detecting minimal residual disease (MRD) in patients with resectable hepatocellular carcinoma (HCC), which could improve peri-surgical management and prognostic predictions.
  • Conducted on 88 HCC patients, the research analyzed tumor and plasma samples to correlate pre-surgical and post-surgical ctDNA levels with recurrence-free survival (RFS) and overall survival (OS).
  • Results indicated that post-surgical MRD status is a significant risk factor for cancer recurrence, even in patients originally classified as low-risk, highlighting its potential as a valuable prognostic tool.
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Article Synopsis
  • * A bilayer scaffold was created by combining a sulfonated PEEK framework with a hydrogel containing aspirin and nano-hydroxyapatite, which resulted in beneficial changes like better bioactivity and increased resistance.
  • * The bilayer scaffold demonstrated improved mechanical compatibility with bone and was shown to be biosafe, indicating its potential for effective clinical applications in bone regeneration.
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Fermentation products, together with food components, determine the sense, nutrition, and safety of fermented foods. Traditional methods of fermentation product identification are time-consuming and cumbersome, which cannot meet the increasing need for the identification of the extensive bioactive metabolites produced during food fermentation. Hence, we propose a data-driven integrated platform (FFExplorer, http://www.

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Summary: The field of synthetic biology lacks a comprehensive knowledgebase for selecting synthetic target molecules according to their functions, economic applications and known biosynthetic pathways. We implemented ChemHub, a knowledgebase containing >90 000 chemicals and their functions, along with related biosynthesis information for these chemicals that was manually extracted from >600 000 published studies by more than 100 people over the past 10 years.

Availability And Implementation: Multiple algorithms were implemented to enable biosynthetic pathway design and precursor discovery, which can support investigation of the biosynthetic potential of these functional chemicals.

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Motivation: The 2019 novel coronavirus outbreak has significantly affected global health and society. Thus, predicting biological function from pathogen sequence is crucial and urgently needed. However, little work has been conducted to identify viruses by the enzymes that they encode, and which are key to pathogen propagation.

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Summary: Living cell strains have important applications in synthesizing their native compounds and potential for use in studies exploring the universal chemical space. Here, we present a web server named as Cell2Chem which accelerates the search for explored compounds in organisms, facilitating investigations of biosynthesis in unexplored chemical spaces. Cell2Chem uses co-occurrence networks and natural language processing to provide a systematic method for linking living organisms to biosynthesized compounds and the processes that produce these compounds.

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The presence of natural toxins, pesticide residues, and illegal additives in food products has been associated with a range of potential health hazards. However, no systematic database exists that comprehensively includes and integrates all research information on these compounds, and valuable information remains scattered across numerous databases and extensive literature reports. Thus, using natural language processing technology, we curated 12,018 food risk components from 152,737 literature reports, 12 authoritative databases, and numerous related regulatory documents.

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