A novel deep learning approach to identify embryo morphokinetics in multiple time lapse systems.

The use of time lapse systems (TLS) in In Vitro Fertilization (IVF) labs to record developing embryos has paved the way for deep-learning based computer vision algorithms to assist embryologists in their morphokinetic evaluation. Today, most of the literature has characterized algorithms that predict pregnancy, ploidy or blastocyst quality, leaving to the side the task of identifying key morphokinetic events. Using a dataset of N = 1909 embryos collected from multiple clinics equipped with EMBRYOSCOPE/EMBRYOSCOPE+ (Vitrolife), GERI (Genea Biomedx) or MIRI (Esco Medical), this study proposes a novel deep-learning architecture to automatically detect 11 kinetic events (from 1-cell to blastocyst).

All-fiber laser source at 1645 nm for lidar measurement of methane concentration and wind velocity.

We report on the realization of an all-fiber laser source that delivers single-frequency pulses at 1645 nm, on a linearly polarized single-mode beam, based on stimulated Raman scattering in passive fibers. The pulse energy reaches 14 µJ for a repetition rate of 20 kHz, and the spectral linewidth is 9.5 MHz for 100 ns square pulses.

Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study.

Objective: To describe pain assessment, the pattern of analgesic and sedative drug use, and adverse drug reactions in a neonatal intensive care unit (NICU) during the postsurgery phase.

Method: Demographic characteristics, pain scores, and drug use were extracted and analyzed from electronic patient medical files for infants after surgery, admitted consecutively between January 2012 and June 2013.

Result: One hundred and sixty-eight infants were included.

Low Osteoporosis Treatment Initiation Rate in Women after Distal Forearm or Proximal Humerus Fracture: A Healthcare Database Nested Cohort Study.

Treatment initiation rates following fragility fractures have often been reported to be low and in recent years numerous programs have been implemented worldwide to increase them. This study aimed at describing osteoporosis (OP) treatment initiation in a representative sample of women who were hospitalized for a distal forearm fracture (DFF) or proximal humerus fracture (PHF) in 2009-2011 in France. The data source was a nationwide sample of 600,000 individuals, extracted from the French National Insurance Healthcare System database.

Eyesafe coherent detection wind lidar based on a beam-combined pulsed laser source.

We report on a coherent wind lidar built with two coherently-beam-combined fiber amplifiers. The lidar performances of the combined-amplifier and the single-amplifier are compared using two criterions: carrier-to-noise ratio and wind speed noise floor. In both cases, lidar performances are not degraded with a combined source and are close to the theoretical optimum.

1 kW peak power, 110 ns single-frequency thulium doped fiber amplifier at 2050 nm.

We report a high power, single frequency, linearly polarized master oscillator power amplifier emitting 110 ns, 1 kW peak power pulses at 2050 nm. A 20% slope efficiency and a beam quality of M2=1.21 are achieved with three-stage double-clad Tm(3+)-doped fiber architecture.

[Determination of the 120-day post prostatic biopsy mortality rate].

Objective: Concerning death-rates were reported following prostate biopsy but the lack of contexts in which event occurred makes it difficult to take any position. Therefore, we aimed to determine the 120-day post-biopsy mortality rate.

Material And Methods: Between 2000 and 2011, 8804 men underwent prostate biopsy in the hospice civils de Lyon.

HPV vaccination among French girls and women aged 14-23 years and the relationship with their mothers' uptake of Pap smear screening: a study in general practice.

Introduction: HPV vaccination is recommended in France for girls aged 14 and for those aged 15-23 before sexual debut or who have become sexually active within the previous year. The first aim was to describe vaccination practice among 14-23-year-old girls visiting a general practitioner. A second objective was to investigate factors associated with starting vaccination among girls aged 14-18, in particular the regular practice of Pap-smear screening (PSS) by their mothers.

Spatially resolved modal spectroscopy of Er:Yb doped multifilament-core fiber amplifier.

The spatially resolved spectral (S2) imaging method is applied on an active microstructured fiber, with a multi-filament core (MFC). This type of fiber has been designed to be the last amplifying stage of a source for a long range coherent lidar. Studying the influence of the bending radius on the modal content with or without gain, we demonstrate that an upper-bound of the high-order modes content can be found by performing the S2 imaging on the bleached fiber.

26 nJ picosecond solitons from thulium-doped single-mode master oscillator power fiber amplifier.

We report on an all single-mode master oscillator power fiber amplifier delivering high energy picosecond solitons at 1960 nm. The Bragg stabilized and self-starting oscillator delivers 62 pJ transform-limited pulses at 11.2 MHz pulse repetition frequency.

Fourth-order cascaded Raman shift in AsSe chalcogenide suspended-core fiber pumped at 2 μm.

Cascaded Raman wavelength shifting up to the fourth order ranging from 2092 to 2450 nm is demonstrated using a nanosecond pump at 1995 nm in a low-loss As(38)Se(62) suspended-core microstructured fiber. These four Stokes shifts are obtained with a low peak power of 11 W, and only 3 W are required to obtain three shifts. The Raman gain coefficient for the fiber is estimated to (1.

Coherent beam combination of narrow-linewidth 1.5 μm fiber amplifiers in a long-pulse regime.

We report what we believe to be the first experimental demonstration of coherent beam combining of two fiber amplifiers in a 100 ns pulse regime using a signal leak between the pulses. Pulses of ∼100 W stimulated-Brillouin-scattering limited peak power are combined with 95% efficiency, a residual phase error of λ/27, and no significant beam quality degradation.

Low loss microstructured chalcogenide fibers for large non linear effects at 1995 nm.

Microstructured optical fibers (MOFs) are traditionally prepared using the stack and draw technique. In order to avoid the interfaces problems observed in chalcogenide glasses, we have developed a new casting method to prepare the chalcogenide preform. This method allows to reach optical losses around 0.

Analysis of the multifilament core fiber using the effective index theory.

Multifilament core (MFC) fibers are a new type of microstructured fiber recently introduced. We investigate their properties using finite element modeling and show that the equivalent step index fiber based on moments theory does not provide similar properties. We propose an effective index theory based on the fundamental space filling mode which allows to predict the MFC properties using a semi-analytical modeling.

Multifilament-core fibers for high energy pulse amplification at 1.5 microm with excellent beam quality.

We report on what we believe to be the first demonstration of an erbium-ytterbium-doped multifilament-core (MFC) fiber for single-mode amplification of narrow linewidth high peak power pulses. A master-oscillator-power-fiber-amplifier laser source has been demonstrated using a 37-filament MFC fiber in the last amplification stage. Pulses with 750 microJ (940 W peak power) and laser linewidth<1 MHz have beam generated with M2 approximately 1.

Characteristics of the Brillouin spectra in Erbium-Ytterbium fibers.

This paper reports the main characteristics of the Stokes spectra for typical pumped and unpumped Erbium-Ytterbium doped fibers. Doped fibers show shorter Brillouin shifts and their spectra are up to 1.6 times broader than undoped fibers.

Evidence of thermal effects in a high-power Er3+-Yb3+ fiber laser.

We analyze the influence of heat generation caused by nonradiative transitions in a high-power 1.55 microm double-clad erbium-ytterbium fiber laser on the Stark level population. At strong pumping rates, 1 microm lasing can start as a result of parasitic reflections.