Purpose: Ozone is a trioxygen molecule that spontaneously degrades into oxygen and oxygen free radicals. This study was designed to assess the effects of topical ozone application on outcomes after corneal collagen cross-linking (CXL).
Methods: Enucleated fresh cadaver yearling sheep eyes ( = 28) were divided into five groups: control (C, = 6), sham (S, = 6), ozone only (Z, = 6), CXL only (X, = 5), and Ozone + CXL (ZX, = 5).