Publications by authors named "Can Yilgor"
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain cancer, making up about 80% of malignant brain tumors, and currently lacks effective treatments due to its complexity and the blood-brain barrier.
- Traditional 2D models do not accurately represent the tumor microenvironment, leading to a growing interest in organ-on-a-chip (OoC) models that mimic human tissue and offer better insights into disease and drug responses.
- The review discusses the advancements in GBM-on-a-chip models, their applications in drug development, and highlights the challenges and future directions for enhancing these innovative research platforms.
Engineered human tissues created by three-dimensional cell culture of human cells in a hydrogel are becoming emerging model systems for cancer drug discovery and regenerative medicine. Complex functional engineered tissues can also assist in the regeneration, repair, or replacement of human tissues. However, one of the main hurdles for tissue engineering, three-dimensional cell culture, and regenerative medicine is the capability of delivering nutrients and oxygen to cells through the vasculatures.
View Article and Find Full Text PDF