CDR1as Deficiency Prevents Photoreceptor Degeneration by Regulating miR-7a-5p/α-syn/Parthanatos Pathway in Retinal Detachment.

Retinal detachment (RD) is the separation of the neural retina from the retinal pigment epithelium, with photoreceptor degeneration being a major cause of irreversible vision loss. Ischemia and hypoxia after RD decreased the level of miR-7a-5p (miR-7) and promoted the expression of its main target, α-synuclein (α-syn), which activated the parthanatos pathway and led to photoreceptor damage. Circular RNA CDR1as, which is an antisense transcript of cerebellar degeneration-related protein 1, functions as a "sponge" for miR-7, thereby regulating its abundance and activity.

Deferiprone protects photoreceptors by inhibiting ferroptosis after experimental retinal detachment.

The detachment of the retinal neuroepithelium from the retinal pigment epithelium (RPE), often due to a retinal tear and subsequent subretinal fluid (SRF) accumulation, is a critical factor leading to photoreceptor cells (PR) death and permanent vision impairment in retinal detachment (RD) scenarios. Predicting postoperative visual recovery is challenging, even with surgical reattachment. Research has indicated that increased iron and transferrin (TF) saturation in the vitreous fluid (VF) correlates with poorer visual outcomes, suggesting a potential role for ferroptosis, a form of regulated cell death, in PR following RD.

Paquinimod attenuates retinal injuries by suppressing the S100A9/TLR4 signaling in an experimental model of diabetic retinopathy.

Diabetic retinopathy (DR), the most common ocular complication of diabetes mellitus (DM), has exhibited an increase in incidence over the past decade. S100 calcium-binding protein A9 (S100A9) plays a significant role in inflammation and cancer. Toll-like receptor 4 (TLR4), a transmembrane receptor, initiates signaling cascades upon ligand binding.

Effect of Preoperative Glucocorticoid Application on Vitreous Parthanatos-Related Protein Expression in Patients with Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment.

Purpose: The protein concentrations of apoptosis inducing factor (AIF), macrophage migration inhibitory factor (MIF), interleukin-1β (IL-1β), poly ADP ribose polymerase-1 (PARP-1), poly (ADP-ribose) (PAR), α-synuclein (α-SYN), monocyte chemotactic protein‑1 (MCP-1) and tumor necrosis factor-α (TNF-α) in the vitreous of eyes with rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) were observed and analyzed.

Methods: A total of 57 patients' samples were included. 30 patients with RRD were set as the control group, 27 patients with RRDCD were set as the experimental group (16 patients with preoperative glucocorticosteroid (GC+) and 11 patients without preoperative glucocorticosteroid (GC-)).

Interaction energy flow paths analysis of PMSG-based wind power integrated systems during LVRT and its parameter adjustment strategy.

To solve the problem of oscillation instability in permanent magnetic synchronous generator (PMSG)-based wind power connected systems during low-voltage ride through (LVRT) process, a parameter adjustment strategy based on interaction energy path optimization is proposed in this paper. Firstly, a modular state-space model of PMSG under fault transient conditions is constructed, and the system is divided into five subsystems. Then, the dynamic energy function of subsystems reflecting the oscillation stability of the system is derived.

Positive and Negative Contribution from Lead-Oxygen Groups and Halogen Atoms to Birefringence: A First Principles Investigation.

Oxyhalides, containing oxygen and halogen atoms and combining the advantages of oxides and halides in geometry and optical response, have great potential in optical materials. In this study, the electronic structures and the optical properties of the PbOX (X = Cl, Br, I) compounds have been investigated using the first principles method. The results show that these compounds have birefringence at 0.

The global research of bladder cancer immunotherapy from 2012 to 2021: A bibliometric analysis.

Intravesical instillation of Bacillus Calmette-Guérin has been used as an immunotherapy to treat superficial bladder cancer for almost half a century. In recent years, the approval of several monoclonal antibody treatments has transformed the treatment landscape for patients with muscle-invasive or metastatic uroepithelial carcinoma. The purpose of this study was to conduct a thorough review of immunotherapy in bladder cancer through a bibliometric approach.

Is color source retrieval sensitive to emotion? Electrophysiological evidence from old/new effects.

It has been proved that item memory and source memory are two dissociable processes, as reflected by differential influence at behavioral and electrophysiological levels, the latter being evidenced by the ERP old/new effects. Specially for source memory, the retrieval of color source may be unique from recollecting other types of contextual information, which can be seen from the late posterior negativity (LPN). However, the mediation of emotional valence on the old/new effects for verbal stimuli encoded in colors remains unknown.

The Modulation of Stimulus Familiarity on the Repetition Effect in Duration Judgment.

The repetition of a stimulus often produces a shorter subjective duration than does the presentation of a novel item. To test whether familiarity mediates the repetition compression effect, the present study compared the influence of repeated words and pseudowords on apparent duration, using a duration discrimination task. We found a similar magnitude of temporal compression for the repeated-word and repeated-pseudoword conditions.

Emotion Recognition Positively Correlates with Steady-state Visual Evoked Potential Amplitude and Alpha Entrainment.

Emotion recognition reflects the psychological and physiological status of humans. Numerous studies have investigated the neural mechanisms of emotion recognition based on electroencephalography (EEG) features. In the previous study, emotion target was presented under a static or irregular background, which made the response highly time-locked.

Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl in mice.

Objective: The present work aimed to investigate the effects of AdipoRon against acute hepatitis and liver fibrosis induced by carbon tetrachloride (CCl) in mice.

Methods: C57BL/6 mice were randomly divided into five groups: control, model, AdipoRon groups (three different dosages), CCl was administered to induce acute hepatitis or liver fibrosis except for control group. The liver function, inflammatory and fibrotic profiles were evaluated by histology, immunohistochemistry and expression analysis, respectively.

The effects of low levels of trivalent ions on a standard strain of Escherichia coli (ATCC 11775) in aqueous solutions.

Considering the ever-growing usage of trivalent salts in water treatment, for example, lanthanum salts in rare earth, AlCl and FeCl , the effects of different trivalent cations on the bacterium Escherichia coli (E. coli) ATCC 11775 strain have been studied in aqueous solutions. From colony incubation studies, the colony-forming unit (CFU) densities were found to decrease significantly in the presence of even low levels (10  mol/L) of lanthanum chloride.

Small pyramidal textured ultrathin crystalline silicon solar cells with double-layer passivation.

Ultrathin crystalline silicon solar cells are a promising technology roadmap to achieve more cost effectiveness. However, experimental reports on ultrathin crystalline silicon cells with thickness less than 20 µm are rare. Here, we experimentally fabricate and investigate ultrathin monocrystalline silicon solar cells consisting of 16 µm-silicon base thickness and low-cost front random pyramidal texture with the feature size of 1-2 µm.

Treatment of pharmaceutical wastewater containing recalcitrant compounds in a Fenton-coagulation process.

The advanced treatment using integrated Fenton's reaction and coagulation process was investigated in this study. Before the advancement, the pharmaceutical wastewater containing lincomycin hydrochloride was pretreated by UASB (upflow anaerobic sludge bed) and a SBR (sequencing batch reactor) process. The residual recalcitrant compounds, measured by gas chromatography-mass spectrometry (GC-MS), mainly consisted of alcohols, phenols, and nitrogenous and sulfur compounds.