A weakly supervised model for incomplete multimodal MRI synthesis with tumor-aware approach.

Background: Magnetic resonance images (MRIs) are a valuable tool in the study of brain tumors, and multimodal sequences provide unique insights into different aspects of brain tumors. However, in clinical practice, missing modalities are often encountered due to various factors. This makes it difficult to obtain comprehensive and reliable information related to brain tumors.

Clinical Efficiency of Metagenomic Next-Generation Sequencing in Sputum for Pathogen Detection of Patients with Pneumonia According to Disease Severity and Host Immune Status.

Purpose: Severe pneumonia causes the highest mortality rate in immunocompromised patients. This study aimed to investigate the pathogen diagnostic efficacy of metagenomic next-generation sequencing (mNGS) using sputum sample in patients with pneumonia according to patients' disease severity and immune conditions.

Patients And Methods: A total of 180 patients suffering from pneumonia were recruited, and sputum samples were collected in duplicate for pathogen detection by both conventional microbiological tests (CMT) and mNGS.

A semi-supervised classification RBM with an improved fMRI representation algorithm.

Background And Objective: Training an effective and robust supervised learning classifier is not easy due to the limitations of acquiring and labeling considerable human functional magnetic resonance imaging (fMRI) data. Semi-supervised learning uses unlabeled data for feature learning and combines them into labeled data to build better classification models.

Methods: Since no premises or assumptions are required, a restricted Boltzmann machine (RBM) is suitable for learning data representation of neuroimages.

Hesperetin ameliorates lipopolysaccharide-induced acute lung injury via the miR-410/SOX18 axis.

Hesperetin (Hesp), a dihydroflavone, has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, and antitumor effects, as well as cardiovascular protection. It also has protective effects against acute lung injury (ALI); however, the exact mechanism remains unclear. In the present study, the protective effects and mechanism of Hesp in the lungs were investigated.

Combined effect of salt and drought on boron toxicity in Puccinellia tenuiflora.

Boron toxicity is a worldwide problem, usually accompanied by salt (NaCl) and drought. The combined stresses may induce complex toxicity to the plant. The aim of the present study was to investigate how the combined stresses of salt and drought affect B toxicity in plants.

Developmental toxicity of doxorubicin hydrochloride in embryo-larval stages of zebrafish.

Doxorubicin hydrochloride is widely used to treat various types of cancers. Its therapeutic and side effects are well documented. However, the developmental toxicity of doxorubicin has not been previously described.