Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.

Inflammation caused by infiltrating macrophages and T cells promotes plaque growth in atherosclerosis. Cadherin-11 (CDH11) is a cell-cell adhesion protein implicated in several fibrotic and inflammatory diseases. Much of the research on CDH11 concerns its role in fibroblasts, although its expression in immune cells has been noted as well.

Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.

Calcific aortic valve disease (CAVD) is a condition causing stiffening of the aortic valve, impeding cardiac function and resulting in significant morbidity worldwide. CAVD is thought to be driven by the persistent activation of the predominant cell type in the valve, aortic valve interstitial cells (AVICs), into myofibroblasts, resulting in subsequent calcification and stenosis of the valve. Although much of the research into CAVD focuses on AVICs, the aortic valve endothelial cells (AVECs) have been shown to regulate AVICs and maintain tissue homeostasis.

Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis.

Calcific aortic valve disease is a progressive fibrocalcific process that can only be treated with valve replacement. Cadherin-11 has recently been identified as a potential therapeutic target for calcific aortic valve disease. The already approved drug celecoxib, a cyclooxygenase-2 inhibitor, binds cadherin-11, and was investigated as a therapeutic against calcific aortic valve disease.

Ionic liquid gel-assisted electrodes for long-term cutaneous recordings.

The integration of an ionic liquid gel on conformal electrodes is investigated for applications in long-term cutaneous recordings. Electrodes made of Au and the conducting polymer PEDOT:PSS coated with the gel show a low impedance in contact with the skin that maintains a steady value over several days, paving the way for non-invasive, long-term monitoring of human electrophysiological activity.