Enriched environment prevents hypernociception and depression-like behavior in a psychiatric disorder and neuropathic pain comorbidity experimental condition.

Pain is a multifactorial debilitating condition associated with some psychiatric comorbidities such as generalized anxiety and depression. Concerning pharmacological treatment, which is often inefficient or associated with intense side effects, the physical and social context may be fundamental for patient's health improvement. In this sense, we sought to assess the impact of an enriched environment (EE) on neuropathic pain (NP) and depression comorbid.

Factors Associated with Performance of Activities and Participation of Brazilian Children and Adolescents with Cerebral Palsy: A Cross-Sectional Study.

The aim of this study was to investigate factors related to performance in daily activities, mobility, social/cognitive skills, and responsibility of Brazilian children/adolescents with cerebral palsy (CP). Multivariate binary logistic regression analyses were performed. A total of 190 children/adolescents participated.

Development and validation of an all-in-one rabies virus Bat-Clade genomic sequencing and host identification protocol.

Rabies virus (RABV), remains a significant public health concern, with bat-maintained lineages accounting for all currently documented cases in Brazil. Despite the availability of pharmacological prophylaxis for humans and animals, the high genetic diversity of RABV in diverse natural bat hosts and continued circulation in multiple animals pose challenges for effective surveillance. Here, we developed and validated a novel, rapidly deployable amplicon-based sequencing approach for RABV genomic surveillance.

Phase I-IIa clinical trial to evaluate the safety, feasibility and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft palate: the BIOCLEFT study protocol.

Introduction: The current gold standard treatment for patients with orofacial clefts is surgical repair of the palatal defect (uranostaphylorrhaphy), which is associated with growth defects and hypoplasia of the maxillofacial structures. This trial aims to evaluate the potential of a bioengineered artificial palate mucosa, created through tissue engineering with autologous stromal and epithelial cells and nanostructured fibrin-agarose biomaterials, to enhance treatment outcomes for patients with unilateral cleft lip and palate.

Methods And Analysis: This phase I-IIa clinical trial aims to evaluate the feasibility and biosafety of a procedure involving grafting bioartificial palate mucosa onto the areas of denudated bone in patients undergoing uranostaphylorrhaphy.

THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY.

Obesity is recognized as a significant risk factor for various types of cancer. Although the incidence of some types of cancer across various primary sites is decreasing due to specific prevention measures (screening programs, smoking cessation), the incidence of neoplasms in the young population shows a significant increase associated with obesity. There is sufficient evidence to say that bariatric surgery has been shown to significantly lower the risk of developing obesity-associated cancers, which are linked to metabolic dysregulation, chronic low-grade systemic inflammation, and hormonal alterations such as elevated levels of insulin and sex hormones.

Polythiophene side chain chemistry and its impact on advanced composite anodes for lithium-ion batteries.

In the development of high-performance lithium-ion batteries (LIBs), the design of polymer binders, particularly through manipulation of side-chain chemistry, plays a pivotal role in optimizing electrode stability, ion transport, and adaptability to the volume changes during cycling. In particular, poly[3-(potassium-4-butanoate)thiophene-2,5-diyl] (P3KBT) increases magnetite and silicon capacity and cycling stability. This work explores the impact of polythiophene alkyl sidechain length on anode characteristics, aiming to enhance performance in LIBs.

Acute cannabidiol treatment reverses behavioral impairments induced by embryonic valproic acid exposure in male mice.

Cannabidiol (CBD), the major non-psychotomimetic compound of the Cannabis sativa plant, has shown promising effects in addressing various symptoms associated with autism spectrum disorder (ASD). This neurodevelopmental disorder typically impacts cognitive, behavioral, social communication, and motor skills domains. However, effective treatments for the wide range of symptoms associated with the disorder are limited and may trigger undesirable effects.

Use of Probiotics and Synbiotics in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO) and Other Gastrointestinal Symptoms After Metabolic Bariatric Surgery: a Systematic Review and Meta-Analysis.

Metabolic bariatric surgery is considered the most effective treatment for severe obesity, however it may be associated with the development of Small Intestinal Bacterial Overgrowth (SIBO) and other gastrointestinal symptoms (GIS). This study conducted a systematic review and meta-analysis to evaluate the effects of probiotics or synbiotics on GIS and SIBO in post- metabolic bariatric surgery patients. Five studies that investigated the effect of probiotics or synbiotics in the treatment of post-surgery GIS were included in the review, with three focusing on SIBO.

Evidence of the efficiency of reverse vaccinology against bovine parasites: A systematic review.

Reverse vaccinology is a novel vaccine development technology that uses genome and proteome analyses through bioinformatics to select antigenic epitopes capable of eliciting an immunological and protective response through a quick and cheap methodology. However, data on its use in animal health are scant and further research is advocated. Therefore, this systematic review aimed to evaluate the evidence of the efficiency of reverse vaccinology in the search for antigens against bovine parasites, as well as its perspectives and limitations.

In Vitro Antimicrobial Activity of Volatile Compounds from the Lichen (L.) Zopf. Against Multidrug-Resistant Bacteria and Fish Pathogens.

Lichens are symbiotic organisms with unique secondary metabolism. Various metabolites from lichens have shown antimicrobial activity. Nevertheless, very few studies have investigated the antimicrobial potential of the volatile compounds they produce.

Multifunctional Metasurface with PIN Diode Application Featuring Absorption, Polarization Conversion, and Transmission Functions.

The objective of this paper is to explore the potential of integrating three distinct functionalities into a thin, single-layer metasurface. Specifically, the study introduces a metasurface design that combines absorption, polarization conversion, and transmission capabilities. The proposed structure consists of a double square loop disposed on a dielectric substrate, which is covered by a superstrate.

Assessment of the adherence to perioperative nutritional care protocols in Brazilian hospitals: The PreopWeek study.

Objectives: The study (PreopWeek) aimed to assess the perioperative nutritional care for major surgical patients in Brazilian hospitals, focusing on adherence to emerging multimodal protocols like Enhanced Recovery After Surgery and Acceleration of Total Postoperative Recovery.

Methods: An observational cross-sectional study was conducted in Brazilian hospitals enrolled voluntarily from June 19 to June 23, 2023 (convenience sample). Data were collected through patient interviews and medical records review.

Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity.

The construction of compound databases (DB) is a strategy for the rational search of bioactive compounds and drugs for new and old diseases. In order to bring greater impact to drug discovery, we propose the development of a DB of bioactive antiviral compounds. Several research groups have presented evidence of the antiviral activity of medicinal plants and compounds isolated from these plants.

Estimating the Distance Between Map Points May Be Related to Forms of Representing the Map´s Scale.

The way a map scale is represented plays a key role in comprehending it. In this research, we examined the relationships between the form of representation of the map's scale (numerical scale, linear graphic scale and circular graphic scale), the user's gender, and the distance between two map objects on user of the distance between two objects on the map (i.e.

[Effectiveness of the Adequate Childbirth Program in reducing cesarean section rates in private maternity hospitals in São Paulo , Brazil].

Cesarean section is a life-saving intervention, but its use without obstetric indication leads to short- and long-term complications. Brazil is internationally known for its high cesarean rates, especially in the private sector. To reverse this problem, the Brazilian National Regulatory for Private Health Insurance and Plans launched the Adequate Childbirth Program, and this retrospective study aims to analyze its effectiveness.

Functioning profile and related impairments of children and adolescents with cerebral palsy - PartiCipa Brazil preliminary results.

Background: Limited information is available about functioning and related impairments of children and adolescents with Cerebral Palsy (CP) in low- and middle-income countries (LMIC) like Brazil. The aim of this study is to describe the characteristics, functioning, and impairments of Brazilian children and adolescents with CP.

Methods: Cross-sectional preliminary study as part of the PartiCipa Brazil multicentered cohort study.

Latin American Study on parenteral and enteral nutritional therapy-ELANPE Study ELANPE Group.

Objective: We describe the status of medical nutrition therapy in adult patients in several hospitals in Latin America in 2023. with the aim of deepening understanding of its implementation and thus, in turn, contributing to the advancement of future guidelines.

Materials And Methods: This is a descriptive, multicenter, cross-sectional study.

Efficacy of in-person versus digital enhanced lifestyle interventions in adults with overweight and obesity.

Background: Lifestyle interventions (LIs) are the cornerstone for obesity management. The Mayo Clinic Diet (MCD) offers two approaches for LIs: the In-Person LI (IPLI) and the Digital Enhanced LI (DELI). The IPLI includes a 2-day in-person program with monthly follow-ups, whereas the DELI provides on-demand digital tools.

Live Cell Painting: New nontoxic dye to probe cell physiology in high content screening.

High-content imaging approaches, in combination with the use of perturbing agents such as small molecules or CRISPR-driven gene editing, have widely contributed to the identification of new therapeutic compounds. Thanks to recent advances in image-analysis methods, the use of high-content screens is increasingly gaining popularity and thus accelerating the discovery of new therapeutics. However, due to the lack of fully biocompatible fluorescent markers, large-scale high-content screens are mostly performed on fixed cells, which complicates the monitoring of changes in cell physiology over time.

CRITICAL VIEW OF SAFETY: A PROSPECTIVE SURGICAL AND PHOTOGRAPHIC ANALYSIS IN LAPAROSCOPIC CHOLECYSTECTOMY - DOES IT HELP TO PREVENT IATROGENIC LESIONS?

Background: The incidence of biliary duct injuries remains higher in laparoscopic cholecystectomy (LC) in comparison to open surgery. The Critical View of Safety (CVS) was introduced by Strasberg as a strategy for reducing this catastrophic complication. AIM: The aim of this study was to evaluate how often an adequate CVS is achieved during LC, the determining factors for its success, and the associated surgical outcomes.

e-EARLY TOGETHER Intervention for Infants at High Risk of Cerebral Palsy: Randomized Controlled Trial Protocol.

Purpose: The purpose of this study is to evaluate the effectiveness of an early intervention program, e-EARLY TOGETHER, that combines goal-oriented training, parental coaching, environmental enrichment in a telehealth approach in a low- and middle-income country.

Methods: Protocol for a randomized controlled clinical trial to evaluate the effectiveness of e-EARLY TOGETHER intervention compared to standard guidelines on outcomes related to development and performance in infants at high risk of cerebral palsy.

Discussion: This protocol will inform and enrich clinical practice related to early intervention in low- and middle-income countries.

Description of sp. nov., a Novel Cyanobacterium from the Nile River Basin, Egypt: A Polyphasic Analysis and Comparative Study of Related Genera in the Oculatellales Order.

In this paper, we examine the filamentous cyanobacterial strain NILCB16 and describe it as a new species within the genus . The original population was sampled from a mat growing in an irrigation canal in the Nile River, Egypt. Initially classified under or the strain is a potential producer of the toxins microcystin and β-N-Methylamino-L-Alanine (BMAA).

Parenting Practices to Prevent Childhood Obesity Among Hispanic Families: A Systematic Literature Review.

Childhood obesity disproportionately affects Hispanic families and remains an unresolved public health concern. Interventions to enhance health-related parenting practices may be a promising strategy to lower the risk for childhood obesity. However, there are scarce data on which parenting practices would be culturally relevant and contribute to lower the risk for childhood obesity among Hispanic families in the United States.