Development and Validation of an Automated Classifier to Diagnose Acute Otitis Media in Children.

Importance: Acute otitis media (AOM) is a frequently diagnosed illness in children, yet the accuracy of diagnosis has been consistently low. Multiple neural networks have been developed to recognize the presence of AOM with limited clinical application.

Objective: To develop and internally validate an artificial intelligence decision-support tool to interpret videos of the tympanic membrane and enhance accuracy in the diagnosis of AOM.

Detection of highly macrolide-resistant Legionella pneumophila strains from a hotel water network using systematic whole-genome sequencing.

Objectives: Implementation of an antibiotic resistance detection tool in Legionella daily surveillance at the French National Reference Centre for Legionella.

Methods: Systematic WGS of Legionella pneumophila isolates and bioinformatics detection of specific mutations linked to antibiotic resistance. Phenotypic validation of antibiotic resistance detected by WGS was performed by the broth microdilution method.

A Community Outbreak of Legionnaires' Disease with Two Strains of Serogroup 1 Linked to an Aquatic Therapy Centre.

An outbreak of Legionnaires' disease affected 18 people in Montpellier, a town of the south of France, between December 2016 and July 2017. All cases were diagnosed by a positive urinary antigen test. No deaths were reported.

Pest categorisation of .

The EFSA Plant Health Panel performed a pest categorisation of Padwick. is a well-characterised fungal plant pathogen with opportunistic behaviour, mostly isolated along with other fungal pathogens in symptomatic hosts. It has been reported from Africa, America, Asia and Oceania where it is has been associated with a wide range of symptoms on approximately 25 cultivated and non-cultivated plant species.

Pest categorisation of .

The EFSA Plant Health Panel performed a pest categorisation of Damm, Alizadeh & Toy. Sato, a well-defined fungus of the species complex which has been reported from Africa, Asia and America to cause anthracnose and pre- and post-harvest fruit rots on more than 30 plant genera. The pathogen has not been reported from the EU territory and is not included in EU Commission Implementing Regulation 2019/2072.

Co-infection with Legionella and SARS-CoV-2, France, March 2020.

We describe a March 2020 co-occurrence of Legionnaires' disease (LD) and coronavirus disease in France. Severe acute respiratory syndrome coronavirus 2 co-infections were identified in 7 of 49 patients from LD case notifications. Most were elderly men with underlying conditions who had contracted severe pneumonia, illustrating the relevance of co-infection screening.

Pest categorisation of .

The EFSA Plant Health Panel performed a pest categorisation of Prihast., a well-defined polyphagous fungus of the complex which has been reported from all the five continents to cause anthracnose, bitter rot and leaf spotting diseases on over 90 cultivated and non-cultivated woody or herbaceous plant species. The pathogen is not included in EU Commission Implementing Regulation 2019/2072.

Pest categorisation of .

The EFSA Panel on Plant Health performed a pest categorisation of (Hemiptera: Pseudococcidae) for the European Union (EU) territory. This species is not included in EU Commission Implementing Regulation 2019/2072. is native to North America and has spread to all continents except Antarctica.

Pest categorisation of .

The EFSA Panel on Plant Health performed a pest categorisation of the citrus fruit midge, Jiang (Diptera: Cecidomyiidae), for the territory of the EU. This species is not included in EU Commission Implementing Regulation 2019/2072. This oligophagous species, which feeds on spp.

Pest categorisation of .

The EFSA Panel on Plant Health performed a pest categorisation of (Coleoptera: Curculionidae) for the EU territory. This species is not included in EU Commission Implementing Regulation 2019/2072. is a polyphagous pest native to South Africa which has spread to Australia and New Zealand, Reunion and St Helena.

Underdetection of cases of COVID-19 in France threatens epidemic control.

As countries in Europe gradually relaxed lockdown restrictions after the first wave, test-trace-isolate strategies became critical to maintain the incidence of coronavirus disease 2019 (COVID-19) at low levels. Reviewing their shortcomings can provide elements to consider in light of the second wave that is currently underway in Europe. Here we estimate the rate of detection of symptomatic cases of COVID-19 in France after lockdown through the use of virological and participatory syndromic surveillance data coupled with mathematical transmission models calibrated to regional hospitalizations.

Transmission of Legionnaires' Disease through Toilet Flushing.

We describe 2 cases of healthcare-associated Legionnaires' disease in patients in France hospitalized 5 months apart in the same room. Whole-genome sequencing analyses showed that clinical isolates from the patients and isolates from the room's toilet clustered together. Toilet contamination by Legionella pneumophila could lead to a risk for exposure through flushing.

First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020.

A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. The epidemic quickly disseminated from Wuhan and as at 12 February 2020, 45,179 cases have been confirmed in 25 countries, including 1,116 deaths. Strengthened surveillance was implemented in France on 10 January 2020 in order to identify imported cases early and prevent secondary transmission.

Adaptation of Amoeba Plate Test To Recover Legionella Strains from Clinical Samples.

The isolation of from respiratory samples is the gold standard for diagnosis of Legionnaires' disease (LD) and enables epidemiological studies and outbreak investigations. The purpose of this work was to adapt and to evaluate the performance of an amoebic coculture procedure (the amoeba plate test [APT]) for the recovery of strains from respiratory samples, in comparison with axenic culture and liquid-based amoebic coculture (LAC). Axenic culture, LAC, and APT were prospectively performed with 133 respiratory samples from patients with LD.

Case Study of High-Dose Ketamine for Treatment of Complex Regional Pain Syndrome in the Pediatric Intensive Care Unit.

Complex regional pain syndrome (CRPS) is a life-altering and debilitating chronic pain condition. The authors are presenting a case study of a female who received high-dose ketamine for the management of her CRPS. The innovative treatment lies not only within the pharmacologic management of her pain, but also in the fact that she was the first patient to be admitted to our pediatric intensive care unit solely for pain control.

Epidemiologic characteristics associated with ST23 clones compared to ST1 and ST47 clones of Legionnaires disease cases in France.

In France, approximately 1200 cases of Legionnaires disease (LD) are reported annually, and isolates are available for approximately 20% of cases identified since 2000. All Legionella pneumophila serogroup 1 (sg1) isolates are characterized by sequence-based typing at the National Reference Centre. LD cases caused by L.

Legionnaires' disease in France.

The aim of this review was to describe the current knowledge of Legionnaires' disease (LD) illustrated by the epidemiological situation in France in 2013. LD is a severe pneumonia commonly caused by Legionella pneumophila serogroup 1. The diagnosis is usually based on the urinary antigen test.

The Greater Metropolitan Medical Alumni Council (GMMAC): the realization of a need.

Objective: The greater New York metropolitan area includes 8 medical schools. Their alumni association (AA) presidents formed a council 6 years ago, meeting 3 times a year to share ideas and identify best practices to solve mutual problems challenging students and alumni.

Methods: A survey of the 8 medical AAs was conducted; all responded, and the results constitute the data in this report.

Legionnaires' disease in France: sensitivity of the mandatory notification has improved over the last decade.

The notification rate of Legionnaires' disease (LD) in France was 2.4/100 000 population in 2010, varying across regions with an increasing rate from west to east. Two sources [mandatory notifications (MN) and a survey of hospital laboratories] were used in a capture-recapture study to estimate the number of LD cases and the sensitivity of the MN system at national and regional levels in 2010.

Contribution of amoebic coculture to recovery of Legionella isolates from respiratory samples: prospective analysis over a period of 32 months.

We evaluated the contribution of amoebic coculture to the recovery of Legionella spp. from 379 respiratory samples. The sensitivity of axenic culture was 42.

Factors associated with hospital mortality in community-acquired legionellosis in France.

The aims of this study were to describe the clinical, biological and radiological features of community-acquired (CA) Legionnaires' disease (LD) and identify the predictors of mortality in hospitalised patients. Demographic data, risk factors, clinical and biological features, medical management, complications, and outcome from 540 hospitalised patients with confirmed CA LD were prospectively recorded. 8.

Progress in the surveillance and control of Legionella infection in France, 1998-2008.

Background: In France, the notification of Legionnaires' disease (LD) has been mandatory since 1987. Following a study showing an important under-reporting of the disease, the surveillance system was strengthened in 1997: the urinary antigen detection test was introduced as a new diagnostic tool and guidelines for prevention and control of the disease were implemented. After these measures, the incidence of LD increased gradually, reaching 2.

Cluster of Legionnaires' disease associated with a public whirlpool spa, France, April-May 2010.

In May 2010, a cluster of three cases of Legionnaires' disease was identified in France. The results of the epidemiological, environmental and microbiological investigations allowed the rapid identification of a public whirlpool spa as the most probable source of contamination and the implementation of appropriate control measures. This investigation has stressed the need for good cooperation between partners and the importance of the molecular analysis of Legionella strains.