Comprehensive Characterization of Oils and Fats of Six Species from the Colombian Amazon Region with Industrial Potential.

The Colombian Amazon is a megadiverse region with high potential for commercial use in the pharmaceutical, food, and cosmetic industries, constantly expanding and looking for new alternatives from natural resources; unfortunately, few characterization reports of its profitable non-timber species in Colombia have been conducted. This work aimed to perform a comprehensive analysis of traditionally used species: (Andiroba), (Asai), (Miriti), (Murumuru), (Sacha Inchi), and H.Karst (Cacay).

Ontogenetic Changes in the Chemical Profiles of Species.

The chemical composition of seedlings and adult plants of several species were analyzed by H NMR spectroscopy combined with principal component analysis (PCA) and HPLC-DAD, HPLC-HRESIMS and GC-MS data. The chromatographic profile of crude extracts from leaves of species showed remarkable differences between seedlings and adult plants. Adult leaves of accumulate dihydrobenzofuran neolignans, contain tetrahydrofuran lignans, and prenylated benzoic acids are found in adult leaves of and .

Insights into the interaction and binding mode of a set of antifungal azoles as inhibitors of potential fungal enzyme-based targets.

Azole-containing compounds are a kind of chemical entities of natural and synthetic origin having a wide-range of activities. They are therefore considered as important moieties for fungicide development, mostly due to the possible action on several enzyme-based targets. As part of our research on fungicidal agents, the relationship between the ligand-enzyme affinities of several synthetic azole-containing compounds against a set of fungal enzyme-based targets was in silico evaluated through molecular docking.