Publications by authors named "Camille Runel"
Importance: In children with sickle cell anemia (SCA), high transcranial Doppler (TCD) velocities are associated with stroke risk, which is reduced by chronic transfusion. Whether matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) can reduce velocities in patients with SCA is unknown.
Objective: To determine the association of MSD-HSCT with TCD velocities as a surrogate for the occurrence of ischemic stroke in children with SCA.
Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404).
Sylvie Chevret Suzanne Verlhac Elisabeth Ducros-Miralles Jean-Hugues Dalle Regis Peffault de Latour Camille Runel
Contemp Clin Trials
November 2017
Article Synopsis
- Kids with sickle cell anemia have a higher chance (11%) of having a stroke before they're 18, but regular blood transfusions can help reduce this risk.
- The DREPAGREFFE study is testing if getting a stem cell transplant from a sibling is better than blood transfusions for these kids, while looking at their health and quality of life.
- The goal is to see if the stem cell transplant leads to better results (like lower blood flow speeds in the brain) compared to just getting transfusions.