Publications by authors named "Camille Prefontaine"
Article Synopsis
- Mell 1913 is a butterfly species unique to China, primarily found in forest canopies, and its mitochondrial genome has been sequenced, revealing a typical butterfly gene arrangement.
- The mitochondrial genome comprises 13 protein-coding genes, 22 tRNAs, and 2 rRNAs, with notable aspects such as atypical start codons and completing stop codons inferred from the mRNA.
- Phylogenetic analysis indicates that Mell 1913's mitogenome is closely related to other butterflies in the Coliadinae subfamily, supporting some previous molecular studies while challenging a morphology-based hypothesis on its relationships.
Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells.
Am J Physiol Endocrinol Metab
October 2024
Type 1 diabetes (T1D) is a chronic metabolic disease resulting from an autoimmune destruction of pancreatic beta cells. Beta cells activate various stress responses during the development of T1D, including senescence, which involves cell cycle arrest, prosurvival signaling, and a proinflammatory secretome termed the senescence-associated secretory phenotype (SASP). We previously identified growth and differentiation factor 15 (GDF15) as a major SASP factor in human islets and human EndoC-βH5 beta cells in a model of DNA damage-mediated senescence that recapitulates features of senescent beta cells in T1D.
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