Publications by authors named "Camille Pelletier"
Whole-genome sequencing is widely used to better understand the transmission dynamics, the evolution and the emergence of new variants of viral pathogens. This can bring crucial information to stakeholders for disease management. Unfortunately, aquatic virus genomes are usually difficult to characterize because most of these viruses cannot be easily propagated .
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- The study investigates the genetic diversity of Ostreid herpesvirus 1 (OsHV-1), which causes Pacific oyster mortality syndrome, across major oyster-farming regions in France.
- Using ultra-deep sequencing and advanced bioinformatics, researchers assembled 21 new OsHV-1 genomes to analyze their genetic variations and evolutionary relationships.
- The findings indicate that the Marennes-Oléron Bay is the main source of OsHV-1 diversity, highlighting the impact of oyster transfer practices on viral dispersion and demonstrating the applicability of phylodynamic methods to DNA viruses.
Article Synopsis
- Mortality outbreaks in young Pacific oysters, primarily caused by the herpesvirus ostreid herpesvirus 1 (OsHV-1), have significantly impacted oyster farming worldwide.
- Recent studies suggest that autophagy, a cellular degradation process, plays a crucial role in the oyster's response to OsHV-1 infection.
- An experimental study demonstrated that autophagy was activated in various oyster tissues after infection, highlighting different regulatory mechanisms and confirming its importance in fighting the virus.
Article Synopsis
- Virus outbreaks are often unpredictable, especially for DNA viruses with low mutation rates, but whole-genome sequencing can help track genetic changes over time.
- This study focuses on the Ostreid herpesvirus 1 (OsHV-1), a virus that has caused significant economic and ecological damage in Europe since its new variant emerged in 2008.
- The analysis shows enough genetic diversity and evolution in OsHV-1 over the last 30 years, with evidence of selective pressures affecting certain genomic regions and variant genotypes found within individual hosts.