Publications by authors named "Camille Lesueur"
Article Synopsis
- 2-Fluorodeschloroketamine (2F-DCK) is a ketamine derivative linked to serious health issues, prompting this study to explore its metabolism using human liver microsomes and authentic samples from drug users.
- The analysis involved advanced techniques like liquid chromatography and high-resolution accurate mass spectrometry, identifying 26 potential metabolites, with 15 newly reported.
- Key findings highlight the reliability of nor-2F-DCK as a target for testing, alongside new metabolites detected in urine and hair, confirming its presence in significant concentrations following chronic use.
Article Synopsis
- 3-Hydroxyeticyclidine (3-HO-PCE) is a lesser-known ketamine derivative that causes dissociative and euphoric effects, but its pharmacological properties and toxicity are not well understood.
- A study investigated the metabolism of 3-HO-PCE for the first time, analyzing drug users' urine and hair samples to identify metabolites that could help in overdose detection.
- The research found 15 metabolites, suggested two reliable biomarkers for urine and hair screening, and highlighted specific metabolites for targeted long-term monitoring and detection of 3-HO-PCE.
