Publications by authors named "Camille Lenzi"
Several studies have investigated the effect of parental age on biological parameters such as reproduction, lifespan, and health; however, the results have been inconclusive, largely due to inter-species variation and/or modest effect sizes. Here, we examined the effect of parental age on the lifespan, reproductive capacity, and locomotor activity of genetic isogenic lines of the nematode and the fruit fly . We found that the progeny of successive generations of old parents had significantly shorter lifespans than the progeny of young parents in both species.
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- - The study explores how cells sense DNA danger signals in their environment and trigger an immune response, specifically the production of type I interferon-β (IFN-β), through a novel immune-metabolic mechanism.
- - Researchers identified that the enzyme ADA2, which breaks down extracellular deoxyadenosine (dAdo) into deoxyinosine (dIno), plays a crucial role in this response; reducing ADA2 activity leads to increased dAdo entry into cells, resulting in dIno accumulation.
- - Increased dIno affects the methionine cycle, causing epigenomic changes that enhance immune responses by stimulating cytosolic dsRNA sensors, ultimately leading to a boosted production of IFN
Elevations of intracellular free Ca concentration ([Ca]) are a potent trigger for Weibel-Palade body (WPB) exocytosis and secretion of von Willebrand factor (VWF) from endothelial cells; however, the identity of WPB-associated Ca-sensors involved in transducing acute increases in [Ca] into granule exocytosis remains unknown. Here, we show that synaptotagmin 5 (SYT5) is expressed in human umbilical vein endothelial cells (HUVECs) and is recruited to WPBs to regulate Ca-driven WPB exocytosis. Western blot analysis of HUVECs identified SYT5 protein, and exogenously expressed SYT5-mEGFP localised almost exclusively to WPBs.
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