Publications by authors named "Camille K Stevenson"
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) affects up to 25% of people worldwide, leading to fat buildup in liver cells, with its severe form, metabolic dysfunction-associated steatohepatitis (MASH), causing inflammation and potential liver transplants.
- Research shows BRUCE, a liver cancer suppressor, is decreased in MASLD/MASH patients, and its role in these conditions needs further exploration, particularly in combination with the tumor suppressor PTEN.
- In experiments with liver-specific double knockout mice (BRUCE and PTEN), BRUCE-deficient mice showed no liver disease, while the double knockout developed significant steatosis, inflammation, and fibrosis, suggesting BRUCE helps regulate mitochondrial function
