Small networks of expressed genes in the whole blood and relationships to profiles in circulating metabolites provide insights in inter-individual variability of feed efficiency in growing pigs.

Background: Feed efficiency is a research priority to support a sustainable meat production. It is recognized as a complex trait that integrates multiple biological pathways orchestrated in and by various tissues. This study aims to determine networks between biological entities to explain inter-individual variation of feed efficiency in growing pigs.

Fixing molecular complexes in BioPAX standards to enrich interactions and detect redundancies using semantic web technologies.

Motivation: Molecular complexes play a major role in the regulation of biological pathways. The Biological Pathway Exchange format (BioPAX) facilitates the integration of data sources describing interactions some of which involving complexes. The BioPAX specification explicitly prevents complexes to have any component that is another complex (unless this component is a black-box complex whose composition is unknown).

Towards a reproducible interactome: semantic-based detection of redundancies to unify protein-protein interaction databases.

Motivation: Information on protein-protein interactions is collected in numerous primary databases with their own curation process. Several meta-databases aggregate primary databases to provide more exhaustive datasets. In addition to exhaustivity, aggregation contributes to reliability by providing an overview of the various studies and detection methods supporting an interaction.