The magnitude of the partial volume effect in SPECT imaging of the kidneys: a phantom study.

Background: Single-photon emission computed tomography (SPECT) can cause an over- or underestimation of tissue activity concentration due to limitations in spatial resolution compared to the structures under study. This is commonly referred to as partial volume effect (PVE). Ideally, the PVE should be controlled for and corrected.

Dissimilar DNA Damage to Blood Lymphocytes After Lu-Labeled DOTATOC or Prostate-Specific Membrane Antigen Therapy.

DNA double-strand breaks in cells of radionuclide-treated patients are quantifiable by immunofluorescence microscopy, using phosphorylation of histone-variant H2AX (γ-H2AX) to mark radiation-induced foci (RIFs). Using this method, we compared excess RIFs side by side in recipients of Lu-DOTATOC or Lu-prostate specific membrane antigen-617 (PSMA) radioligands. We also examined relations between blood dose and dose rate, RIFs, and platelet counts.