Publications by authors named "Camille Jacquet"
A three-step sequence for the synthesis of α-arylated cyclohexanones and the most challenging cycloheptanones is reported. First, an efficient one-pot synthesis of β,β'-disubstituted benzylidene cycloalkanes (styrenes) using the palladium-catalyzed Barluenga reaction from readily available feedstock chemicals is described. Furthermore, an epoxidation followed by the House-Meinwald rearrangement (HMR) of spiro-epoxides is reported to produce a number of α-arylated cycloalkanones upon ring expansion.
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- Researchers synthesized three series of indeno[1,2-c]isoquinolines with a ferrocenyl component to explore their effects on DNA interactions and cancer cell inhibition.
- The ferrocenyl was strategically placed either as a linker between nitrogen atoms or at the end of a carbon chain to assess its influence on topoisomerase I and II inhibition.
- Results indicated that the ferrocenyl addition improved topoisomerase II inhibition, and many compounds exhibited significant growth inhibition against the MDA-MB-231 breast cancer cell line, with IC50 values in the micromolar range.