DLX5/6 GABAergic Expression Affects Social Vocalization: Implications for Human Evolution.

DLX5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation. The DLX5/6 locus is regulated by FoxP2, a gene involved in language evolution and has been associated with neurodevelopmental disorders and mental retardation. Targeted inactivation of Dlx5/6 in mouse GABAergic neurons (Dlx5/6VgatCre mice) results in behavioral and metabolic phenotypes notably increasing lifespan by 33%.

and expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan.

and encode two homeobox transcription factors expressed by developing and mature GABAergic interneurons. During development, play a role in the differentiation of certain GABAergic subclasses. Here we address the question of the functional role of Dlx5/6 in the mature central nervous system.

Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells.

Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation (NCC) generates severely hypomorphic lower jaws that present typical maxillary traits.

Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain.

Background: It has been repetitively shown that the transcription factors and are drastically downregulated in endometriotic lesions when compared with eutopic endometrium. These findings suggest that regulatory cascades involving DLX5/6 might be at the origin of endometriosis symptoms such as chronic pelvic pain (CPP). We have shown that inactivation of and in the mouse uterus results in an endometrial phenotype reminiscent of endometriosis.